| pubmed-article:2439228 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2439228 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:2439228 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:2439228 | lifeskim:mentions | umls-concept:C0036186 | lld:lifeskim |
| pubmed-article:2439228 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2439228 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:2439228 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2439228 | pubmed:dateCreated | 1987-7-28 | lld:pubmed |
| pubmed-article:2439228 | pubmed:abstractText | Whole-cell and single-channel calcium currents in enzymatically isolated dog saphenous vein cells were recorded by the patch-clamp method. Test pulses to negative potentials from holding potentials of -90 to -40 mV elicited currents that inactivated quickly and in a voltage-dependent manner (called I low for low threshold). A second calcium current persisted even at relatively positive holding potentials of -30 to -10 mV, required stronger depolarizations for maximum current, and inactivated slowly (I high for high threshold). I high transported barium more than calcium, whereas I low transported the two ions equally. Single-channel current records (90 mM barium) showed a larger conductance that activated at relatively positive potentials and a smaller (about one-third) conductance that activated at weak depolarizations. Nitrendipine suppressed I high, and the effect was voltage dependent as observed in cardiac cells, although block of resting channels was much greater in vein cells (KR approximately 10(-8) M). Exposure to the stereoisomer (-)Bay K 8644 increased I high but not I low. The (-)Bay K 8644 also increased the channel activity and prolonged the open time of the larger conductance current. Thus, two types of calcium channels, differing in potential-dependence of activation and inactivation, calcium/barium selectivity, single-channel conductance, and sensitivities to dihydropyridines were identified in smooth muscle cells isolated from a large cutaneous vein. | lld:pubmed |
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| pubmed-article:2439228 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2439228 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2439228 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2439228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2439228 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2439228 | pubmed:issn | 0009-7330 | lld:pubmed |
| pubmed-article:2439228 | pubmed:author | pubmed-author:BrownA MAM | lld:pubmed |
| pubmed-article:2439228 | pubmed:author | pubmed-author:AllenJJ | lld:pubmed |
| pubmed-article:2439228 | pubmed:author | pubmed-author:SeidelC LCL | lld:pubmed |
| pubmed-article:2439228 | pubmed:author | pubmed-author:YataniAA | lld:pubmed |
| pubmed-article:2439228 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2439228 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:2439228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2439228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2439228 | pubmed:pagination | 523-33 | lld:pubmed |
| pubmed-article:2439228 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2439228 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2439228 | pubmed:articleTitle | Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein. | lld:pubmed |
| pubmed-article:2439228 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2439228 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2439228 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2439228 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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