| pubmed-article:2436254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0001465 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0035179 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:2436254 | lifeskim:mentions | umls-concept:C1706498 | lld:lifeskim |
| pubmed-article:2436254 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:2436254 | pubmed:dateCreated | 1987-5-12 | lld:pubmed |
| pubmed-article:2436254 | pubmed:abstractText | The carboxy terminal part of the proenkephalin A sequence is the 31 amino acid peptide B, which has as its final seven amino acids the sequence of the opioid peptide Met-enkephalyl-Arg6-Phe7. Using a radioimmunoassay which recognises both these peptides we have investigated the relative amounts of peptide B and Met-enkephalyl-Arg6-Phe7 in a human neuroblastoma cell line. We show that these cells contain peptide B-like immunoreactivity but not its heptapeptide fragment. This may be due to lack of proteolytic activity cleaving Met-enkephalyl-Arg6-Phe7 from its precursor, peptide B. On treatment with dibutyryl cyclic AMP the level of immunoreactivity approximately doubles, due to increased amounts of peptide B-like immunoreactivity. Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells. The results are discussed with respect to peptide processing. | lld:pubmed |
| pubmed-article:2436254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2436254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2436254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2436254 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2436254 | pubmed:issn | 0167-0115 | lld:pubmed |
| pubmed-article:2436254 | pubmed:author | pubmed-author:BoarderM RMR | lld:pubmed |
| pubmed-article:2436254 | pubmed:author | pubmed-author:AdamsMM | lld:pubmed |
| pubmed-article:2436254 | pubmed:author | pubmed-author:MarriottDD | lld:pubmed |
| pubmed-article:2436254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2436254 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:2436254 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:2436254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2436254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2436254 | pubmed:pagination | 251-9 | lld:pubmed |
| pubmed-article:2436254 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:meshHeading | pubmed-meshheading:2436254-... | lld:pubmed |
| pubmed-article:2436254 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2436254 | pubmed:articleTitle | Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine. | lld:pubmed |
| pubmed-article:2436254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2436254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
