| pubmed-article:2435897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C0027749 | lld:lifeskim |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C0025251 | lld:lifeskim |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C0017547 | lld:lifeskim |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2435897 | lifeskim:mentions | umls-concept:C0038078 | lld:lifeskim |
| pubmed-article:2435897 | pubmed:dateCreated | 1987-5-13 | lld:pubmed |
| pubmed-article:2435897 | pubmed:abstractText | The effects of a range of neuropeptides were investigated on the membrane potential of the Schwann cells of the giant nerve fibre of the tropical squid. Vasoactive intestinal peptide (VIP) produced a dose-dependent, long-lasting hyperpolarization of the Schwann-cell membrane potential. Among peptides structurally related to VIP, similar effects were produced by peptide histidine isoleucine (PHI) but not by secretin and glucagon. Substance P and somatostatin also hyperpolarized the Schwann-cell membrane potential but via receptor systems distinct from those activated by VIP. Methionine enkephalin ([Met]-enkephalin) blocked the actions of all the above peptides as well as the effects of DL-octopamine and carbachol. The actions of [Met]-enkephalin upon the VIP responses were antagonized by naloxone. VIP produces its effects on the Schwann-cell membrane potential via a receptor system that is independent from those described previously which mediate the effects of carbachol and DL-octopamine. However, VIP can potentiate the effects of the latter systems. The actions of VIP on the Schwann cell are unlikely to be mediated via changes in adenosine 3',5'-cyclic monophosphate (cyclic AMP) levels and are insensitive to changes in the level of extracellular calcium in the superfusate. The actions of VIP are, however, potentiated in the presence of low concentrations of lithium ions suggesting that the VIP receptor may mediate its effects by inducing the hydrolysis of polyphosphatidylinositols in the Schwann-cell membrane. Evidence is presented for the existence of an endogenous VIP-like component in the normal hyperpolarizing action of giant-axon activity on the membrane potential of the Schwann cell. | lld:pubmed |
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| pubmed-article:2435897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2435897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2435897 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2435897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2435897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2435897 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2435897 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2435897 | pubmed:author | pubmed-author:EvansP DPD | lld:pubmed |
| pubmed-article:2435897 | pubmed:author | pubmed-author:VillegasJJ | lld:pubmed |
| pubmed-article:2435897 | pubmed:author | pubmed-author:RealeVV | lld:pubmed |
| pubmed-article:2435897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2435897 | pubmed:volume | 379 | lld:pubmed |
| pubmed-article:2435897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2435897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2435897 | pubmed:pagination | 61-82 | lld:pubmed |
| pubmed-article:2435897 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2435897 | pubmed:meshHeading | pubmed-meshheading:2435897-... | lld:pubmed |
| pubmed-article:2435897 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2435897 | pubmed:articleTitle | Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre. | lld:pubmed |
| pubmed-article:2435897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2435897 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2435897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2435897 | lld:pubmed |
