| pubmed-article:2431001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2431001 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2431001 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:2431001 | lifeskim:mentions | umls-concept:C0074825 | lld:lifeskim |
| pubmed-article:2431001 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2431001 | lifeskim:mentions | umls-concept:C0034580 | lld:lifeskim |
| pubmed-article:2431001 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2431001 | pubmed:dateCreated | 1986-12-30 | lld:pubmed |
| pubmed-article:2431001 | pubmed:abstractText | A specific radioimmunoassay has been established for a growth hormone-dependent insulinlike growth factor (IGF) binding protein (BP) from human plasma. Although the assay was directed against a 53-kD, acid-stable BP subunit, the main immunoreactive BP in the circulation had an apparent molecular mass of approximately 125 kD. Only higher primate species showed cross-reactivity, and IGF-I, IGF-II, and other peptides were without effect. Circulating BP levels in healthy subjects rose threefold from early childhood to puberty. In 65 adults aged 18 to 65, the mean level (+/- SD) was 6.12 +/- 1.43 micrograms/ml, and declined with age. Strong growth hormone-dependence of BP was also seen; there was a 2.2-fold increase in active acromegaly and a 50-80% reduction in growth hormone deficiency. Poorly controlled diabetic subjects had BP levels 40% below normal, whereas in renal failure and third-term pregnancy a mild elevation was seen. Measurement of BP may provide a useful adjunct to IGF assays in growth disorders. | lld:pubmed |
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| pubmed-article:2431001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2431001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2431001 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2431001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2431001 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2431001 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2431001 | pubmed:author | pubmed-author:BaxterR CRC | lld:pubmed |
| pubmed-article:2431001 | pubmed:author | pubmed-author:MartinJ LJL | lld:pubmed |
| pubmed-article:2431001 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2431001 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:2431001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2431001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2431001 | pubmed:pagination | 1504-12 | lld:pubmed |
| pubmed-article:2431001 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2431001 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2431001 | pubmed:articleTitle | Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma. | lld:pubmed |
| pubmed-article:2431001 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2431001 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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