| pubmed-article:2430950 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C0015309 | lld:lifeskim |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C0302583 | lld:lifeskim |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2430950 | lifeskim:mentions | umls-concept:C0314768 | lld:lifeskim |
| pubmed-article:2430950 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2430950 | pubmed:dateCreated | 1987-1-14 | lld:pubmed |
| pubmed-article:2430950 | pubmed:abstractText | A DNA probe from an internal fragment of the exotoxin A structural gene was used to study the effects of selected culture conditions on steady-state levels of exotoxin-specific mRNA in Pseudomonas aeruginosa. Cells grown under conditions of iron deprivation began to synthesize and excrete the exotoxin A polypeptide during the late exponential phase of growth and throughout the stationary phase of growth, concomitant with a sharp increase in exotoxin A mRNA pools in P. aeruginosa cells. The addition of iron to the medium resulted in the failure of these cells to synthesize exotoxin A mRNA, despite significantly enhanced growth. The inhibition of the production of exotoxin A and the accumulation of its mRNA by iron was dose dependent, with a half-maximal inhibitory concentration of FeSO4 of 5 to 10 microM. A blockade of the initiation of transcription by rifampin resulted in the decay of exotoxin A mRNA, with a half-life of approximately 8 to 10 min, depending on the media used for growth. The addition of iron to cells actively engaged in exotoxin A synthesis also resulted in a gradual decrease in the amount of this mRNA in bacteria. However, the rate of decline of mRNA induced by iron was relatively slow (half-life, 90 min), with a considerable lag time between the iron addition and the first detectable effect on mRNA. While iron clearly appears to influence the production of exotoxin A at the transcriptional level, the molecular basis of this effect may involve several interacting factors affecting the initiation of transcription and perhaps mRNA turnover. | lld:pubmed |
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| pubmed-article:2430950 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2430950 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2430950 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2430950 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2430950 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2430950 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:2430950 | pubmed:author | pubmed-author:LorySS | lld:pubmed |
| pubmed-article:2430950 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2430950 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:2430950 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2430950 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2430950 | pubmed:pagination | 1451-6 | lld:pubmed |
| pubmed-article:2430950 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2430950 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2430950 | pubmed:articleTitle | Effect of iron on accumulation of exotoxin A-specific mRNA in Pseudomonas aeruginosa. | lld:pubmed |
| pubmed-article:2430950 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2430950 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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