| pubmed-article:2428921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2428921 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2428921 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2428921 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2428921 | pubmed:dateCreated | 1986-11-14 | lld:pubmed |
| pubmed-article:2428921 | pubmed:abstractText | The ionic conductances in rat basophilic leukemia cells (RBL-2H3) and rat peritoneal mast cells were investigated using the patch-clamp technique. These two cell types were found to have different electrophysiological properties in the resting state. The only significant conductance of RBL-2H3 cells was a K+-selective inward rectifier. The single channel conductance at room temperature increased from 2-3 pS at 2.8 mM external K+ to 26 pS at 130 mM K+. This conductance, which appeared to determine the resting potential, could be blocked by Na+ and Ba2+ in a voltage-dependent manner. Rat peritoneal mast cells had a whole-cell conductance of only 10-30 pS, and the resting potential was close to zero. Sometimes discrete openings of channels were observed in the whole-cell configuration. When the Ca2+ concentration on the cytoplasmic side of the membrane was elevated, two types of channels with poor ion specificity appeared. A cation channel, observed at a Ca2+ concentration of approximately 1 microM, had a unit conductance of 30 pS. The other channel, activated at several hundred micromolar Ca2+, was anion selective and had a unit conductance of approximately 380 pS in normal Ringer solution and a bell-shaped voltage dependence. Antigenic stimulation did not cause significant changes in the ionic conductances in either cell type, which suggests that these cells use a mechanism different from ionic currents in stimulus-secretion coupling. | lld:pubmed |
| pubmed-article:2428921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2428921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428921 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2428921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2428921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2428921 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2428921 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:2428921 | pubmed:author | pubmed-author:FernandezJ... | lld:pubmed |
| pubmed-article:2428921 | pubmed:author | pubmed-author:LindauMM | lld:pubmed |
| pubmed-article:2428921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2428921 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:2428921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2428921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2428921 | pubmed:pagination | 349-68 | lld:pubmed |
| pubmed-article:2428921 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
| pubmed-article:2428921 | pubmed:meshHeading | pubmed-meshheading:2428921-... | lld:pubmed |
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| pubmed-article:2428921 | pubmed:meshHeading | pubmed-meshheading:2428921-... | lld:pubmed |
| pubmed-article:2428921 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2428921 | pubmed:articleTitle | A patch-clamp study of histamine-secreting cells. | lld:pubmed |
| pubmed-article:2428921 | pubmed:publicationType | Journal Article | lld:pubmed |
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