| pubmed-article:2428906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2428906 | lifeskim:mentions | umls-concept:C0206454 | lld:lifeskim |
| pubmed-article:2428906 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:2428906 | pubmed:dateCreated | 1986-11-20 | lld:pubmed |
| pubmed-article:2428906 | pubmed:abstractText | The proliferation of cells in vivo and in culture is regulated by polypeptide growth factors, such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). Growth factors initiate their action by binding to specific cell surface receptors. Receptor occupancy triggers a cascade of physiological changes in the target cell which ultimately lead to DNA synthesis and cell division. Immediate consequences of receptor activation include tyrosine-specific protein phosphorylations, a sustained increase in cytoplasmic pH (pHi) and a transient rise in free Ca2+. The rise in pHi has a permissive effect on DNA synthesis and is mediated by an otherwise quiescent Na+/H+ exchange mechanism in the plasma membrane, which is turned on by protein kinase C, the cellular receptor for phorbol esters. The rapid Ca2+ signal is due to either release from internal stores (PDGF) or net entry via a voltage-independent channel in the plasma membrane (EGF). Phorbol esters, acting via kinase C, inhibit the growth factor-induced Ca2+ signals without affecting resting Ca2+ levels. Monoclonal antibodies against the human EGF receptor can act as partial agonists in that they activate the tyrosine-specific protein kinase without inducing any of the ionic signals. These antibodies fail to induce DNA synthesis when added to quiescent fibroblasts, indicating that the Ca2+ and pHi signals can be dissociated from tyrosine kinase activity and suggesting that these signals are indispensable for the stimulation of cell proliferation. | lld:pubmed |
| pubmed-article:2428906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2428906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2428906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2428906 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2428906 | pubmed:issn | 0022-0949 | lld:pubmed |
| pubmed-article:2428906 | pubmed:author | pubmed-author:MoolenaarW... | lld:pubmed |
| pubmed-article:2428906 | pubmed:author | pubmed-author:De LaatS WSW | lld:pubmed |
| pubmed-article:2428906 | pubmed:author | pubmed-author:DefizeL HLH | lld:pubmed |
| pubmed-article:2428906 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2428906 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:2428906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2428906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2428906 | pubmed:pagination | 359-73 | lld:pubmed |
| pubmed-article:2428906 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:meshHeading | pubmed-meshheading:2428906-... | lld:pubmed |
| pubmed-article:2428906 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2428906 | pubmed:articleTitle | Ionic signalling by growth factor receptors. | lld:pubmed |
| pubmed-article:2428906 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2428906 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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