| pubmed-article:2422266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C0019770 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C2076600 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C1336643 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:2422266 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:2422266 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2422266 | pubmed:dateCreated | 1986-6-13 | lld:pubmed |
| pubmed-article:2422266 | pubmed:abstractText | The clone TA10 is a T3+ T4+ T8- proliferative and cytolytic human T cell clone. This clone has been shown to be specific for the hemagglutinin of influenza A Texas virus and restricted by an HLA class II molecule associated with the DRw8-Dw8.1 phenotype. Here we show that TA10 and all of its subclones can also react with eight HLA-DRw8 negative, Epstein-Barr virus (EBV)-transformed cell lines or phytohemagglutinin blasts in the absence of influenza antigens. All of these cell lines are HLA-DR2/DR4 with a classic DR2 long haplotype. The only nonreactive HLA-DR2/DR4 cell line observed bears a DR2 short haplotype. Only heterozygous HLA-DR2/DR4 but not parental DR2 or DR4 EBV-transformed cell lines can be recognized by TA10, indicating that the cross-reacting determinant is a transcomplementation product between HLA-DR2 and HLA-DR4 haplotypes. DR-specific, but not DQ- or DP-specific monoclonal antibodies, inhibit in the proliferation assay and in the chromium release test both the DRw8-Dw8.1-restricted and the anti-DR2/DR4 reactions. These results show that HLA-DR-restricted, anti-viral human T cell clone can evidence cross-reactivity for allospecific class II molecules of the major histocompatibility complex, and human CTL can recognize transcomplementation products of class II HLA genes. In addition, the results suggest that a beta-chain coded for by an HLA-DR gene and associated with an alpha-chain coded for by a still unidentified but possibly HLA-DQ gene constitute this functional transcomplementation product. | lld:pubmed |
| pubmed-article:2422266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2422266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2422266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2422266 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2422266 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:GomardEE | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:FauchetRR | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:LévyJ PJP | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:SterkersGG | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:MassetMM | lld:pubmed |
| pubmed-article:2422266 | pubmed:author | pubmed-author:HéninYY | lld:pubmed |
| pubmed-article:2422266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2422266 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2422266 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:2422266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2422266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2422266 | pubmed:pagination | 3961-7 | lld:pubmed |
| pubmed-article:2422266 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2422266 | pubmed:meshHeading | pubmed-meshheading:2422266-... | lld:pubmed |
| pubmed-article:2422266 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2422266 | pubmed:articleTitle | An influenza A virus-specific and HLA-DRw8-restricted T cell clone cross-reacting with a transcomplementation product of the HLA-DR2 and DR4 haplotypes. | lld:pubmed |
| pubmed-article:2422266 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2422266 | lld:pubmed |
