| pubmed-article:2413106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2413106 | lifeskim:mentions | umls-concept:C0085286 | lld:lifeskim |
| pubmed-article:2413106 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:2413106 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:2413106 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2413106 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2413106 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2413106 | pubmed:dateCreated | 1985-11-21 | lld:pubmed |
| pubmed-article:2413106 | pubmed:abstractText | Neonatal injection of CBA/HT6T6 (H-2k, Mlsb) mice with adult, Mls-incompatible (CBA/J [H-2k, Mlsd] X CBA/HT6T6)F1 spleen cells results in the abrogation of cell proliferation and interleukin 2 (IL 2) production in bulk mixed lymphocyte cultures, when spleen cells from the inoculated mice are tested at 6 to 8 wk of age with stimulator cells expressing the Mlsd of the tolerizing inoculum. In limiting dilution assays, this tolerant state was manifested in a 25- to 550-fold (280-fold average) decrease in the frequency of precursors of Mlsd-responsive IL 2-producing T cells. Tolerance was specific in that the frequencies of precursors of IL 2-producing cells responding to Con A, allogeneic H-2d, and self-Ia were not affected. The observed low frequency of Mls-responsive cells was due neither to extensive chimerism resulting in the dilution of Mlsd-responsive cells by the nonresponsive F1 cells of the inoculum, nor to the action of suppressor cells. These findings indicate that neonatal injection of Mls-incompatible spleen cells produces a state of specific tolerance by a clonal deletion or inactivation mechanism. This specific tolerance supports the view that 1) the Mls locus encodes or regulates the expression of defined alloantigenic determinants and 2) Mls-incompatible responder mice have specific receptors for Mls determinants on clonally distributed IL 2-producing responder T cells. | lld:pubmed |
| pubmed-article:2413106 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2413106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2413106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2413106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2413106 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2413106 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2413106 | pubmed:author | pubmed-author:LattimeE CEC | lld:pubmed |
| pubmed-article:2413106 | pubmed:author | pubmed-author:StutmanOO | lld:pubmed |
| pubmed-article:2413106 | pubmed:author | pubmed-author:MacphailSS | lld:pubmed |
| pubmed-article:2413106 | pubmed:author | pubmed-author:IshizakaS TST | lld:pubmed |
| pubmed-article:2413106 | pubmed:author | pubmed-author:BykowskyM JMJ | lld:pubmed |
| pubmed-article:2413106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2413106 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:2413106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2413106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2413106 | pubmed:pagination | 2967-74 | lld:pubmed |
| pubmed-article:2413106 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2413106 | pubmed:meshHeading | pubmed-meshheading:2413106-... | lld:pubmed |
| pubmed-article:2413106 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2413106 | pubmed:articleTitle | Specific neonatally induced tolerance to Mls locus determinants. | lld:pubmed |
| pubmed-article:2413106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2413106 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2413106 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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