| pubmed-article:2408612 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0035693 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2408612 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2408612 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2408612 | pubmed:dateCreated | 1985-7-24 | lld:pubmed |
| pubmed-article:2408612 | pubmed:abstractText | The direct effects of alpha- and beta-interferons on isolated mouse pancreatic islets were investigated in vitro and found to be similar. After 7 h incubation with interferon concentrations above 350 units/ml, glucose-stimulated (pro)insulin biosynthesis was significantly inhibited, with only a slight inhibition of total protein biosynthesis. Inhibition could be abolished in the additional presence of an anti-interferon antibody. Interferon did not affect insulin release, total insulin content, or glucose oxidation of the islets. The stimulation of (pro)insulin biosynthesis by adenosine, D-glyceraldehyde, mannose, N-acetylglucosamine and leucine was also inhibited by interferon, with no effect on insulin release. At concentrations of dsRNA (double-stranded RNA) said to induce interferon (1-100 micrograms/ml), glucose-stimulated (pro)insulin biosynthesis was inhibited without significantly affecting insulin release. The dsRNA may itself inhibit stimulated (pro)insulin biosynthesis or may function indirectly by the induction of interferon. | lld:pubmed |
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| pubmed-article:2408612 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2408612 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2408612 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2408612 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2408612 | pubmed:month | May | lld:pubmed |
| pubmed-article:2408612 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2408612 | pubmed:author | pubmed-author:TaylorK WKW | lld:pubmed |
| pubmed-article:2408612 | pubmed:author | pubmed-author:RhodesC JCJ | lld:pubmed |
| pubmed-article:2408612 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2408612 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2408612 | pubmed:volume | 228 | lld:pubmed |
| pubmed-article:2408612 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2408612 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2408612 | pubmed:pagination | 87-94 | lld:pubmed |
| pubmed-article:2408612 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2408612 | pubmed:meshHeading | pubmed-meshheading:2408612-... | lld:pubmed |
| pubmed-article:2408612 | pubmed:meshHeading | pubmed-meshheading:2408612-... | lld:pubmed |
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| pubmed-article:2408612 | pubmed:meshHeading | pubmed-meshheading:2408612-... | lld:pubmed |
| pubmed-article:2408612 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2408612 | pubmed:articleTitle | Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans. | lld:pubmed |
| pubmed-article:2408612 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2408612 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2408612 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2408612 | lld:pubmed |
