| pubmed-article:2408336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2408336 | lifeskim:mentions | umls-concept:C0019168 | lld:lifeskim |
| pubmed-article:2408336 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:2408336 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2408336 | pubmed:issue | 4704 | lld:pubmed |
| pubmed-article:2408336 | pubmed:dateCreated | 1985-7-2 | lld:pubmed |
| pubmed-article:2408336 | pubmed:abstractText | The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. It has been proposed that polypeptides of high molecular weight that contain the pre-S(2) region should be included in future hepatitis B virus (HBV) vaccines. The pre-S(2) region and the S gene product [25 kilodalton (kD)] together compose a polypeptide of high molecular weight (33 kD). As an initial attempt to determine the relevance of the 33-kD polypeptide to development of an HBV vaccine, the murine immune response to pre-S(2)-encoded determinants as compared to S-encoded determinants on the same polypeptide was examined. The results indicate (i) the pre-S(2) region is significantly more immunogenic than the S region of HBsAg, (ii) the 26 amino acid residues at the NH2-terminus of the 33-kD polypeptide represent a dominant antibody binding site on the pre-S(2) region, (iii) the immune response to the pre-S(2) region is regulated by H-2-linked genes distinct from those that regulate the response to the S region, and (iv) immunization of an S region nonresponder strain with HBV envelope particles that contain both the pre-S(2) and S regions can circumvent nonresponsiveness to the S region. | lld:pubmed |
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| pubmed-article:2408336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2408336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2408336 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2408336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2408336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2408336 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2408336 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:KentS BSB | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:NeurathA RAR | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:MichelM LML | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:MilichD RDR | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:TiollaisPP | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:ChisariF VFV | lld:pubmed |
| pubmed-article:2408336 | pubmed:author | pubmed-author:ThorntonG BGB | lld:pubmed |
| pubmed-article:2408336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2408336 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:2408336 | pubmed:volume | 228 | lld:pubmed |
| pubmed-article:2408336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2408336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2408336 | pubmed:pagination | 1195-9 | lld:pubmed |
| pubmed-article:2408336 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2408336 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2408336 | pubmed:articleTitle | Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. | lld:pubmed |
| pubmed-article:2408336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2408336 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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