Linked Life Data

2407540

Source:http://linkedlifedata.com/resource/pubmed/id/2407540

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pubmed-article:2407540pubmed:abstractTextMercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were performed in this model and four anti-GBM monoclonal antibodies (mAb) were obtained. Three of them were laminin specific. Using rabbit anti-idiotype antibodies, cross-reactive idiotypes (CRId) were characterized on anti-laminin antibodies. They were expressed on the three anti-laminin mAb, on kidney-eluted and circulating anti-laminin antibodies. CRId-bearing immunoglobulins were detected transiently in the circulation and paralleled the anti-laminin antibody activity. By immunofluorescence studies on kidney cryostat sections two different CRId were defined. One was localized close to the antigen-combining site since it was not revealed on kidney-bound antibodies, in contrast with the second CRId. This latter CRId was also found deposited in a typical linear pattern in the early phase of the disease and in a granular pattern in the late phase, demonstrating that these CRId are components of immune deposits. Taken together, these results suggest that in this model of T-dependent polyclonal B cell activation, restricted sets of V genes encode for at least a part of the anti-GBM autoantibodies.lld:pubmed
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pubmed-article:2407540pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2407540pubmed:articleTitleSpecificity and cross-reactive idiotypes of anti-glomerular basement membrane autoantibodies in HgCl2-induced autoimmune glomerulonephritis.lld:pubmed
pubmed-article:2407540pubmed:affiliationUnité 28, Institut National de la Santé et de la Recherche Médicale, Hôpital Broussais, Paris, France.lld:pubmed
pubmed-article:2407540pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2407540pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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