| pubmed-article:2406902 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2406902 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2406902 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:2406902 | lifeskim:mentions | umls-concept:C0031526 | lld:lifeskim |
| pubmed-article:2406902 | lifeskim:mentions | umls-concept:C0079413 | lld:lifeskim |
| pubmed-article:2406902 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2406902 | pubmed:issue | 4944 | lld:pubmed |
| pubmed-article:2406902 | pubmed:dateCreated | 1990-3-20 | lld:pubmed |
| pubmed-article:2406902 | pubmed:abstractText | In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210bcr/abl protein. The protein-tyrosine kinase activity and hybrid structure of P210bcr/abl are similar to the oncogene product of the Abelson murine leukemia virus, P160gag/v-abl, which induces acute lymphomas. To determine whether P210bcr/abl can induce chronic myelogenous leukemia, murine bone marrow was infected with a retrovirus encoding P210bcr/abl and transplanted into irradiated syngeneic recipients. Transplant recipients developed several hematologic malignancies; prominent among them was a myeloproliferative syndrome closely resembling the chronic phase of human chronic myelogenous leukemia. Tumor tissue from diseased mice harbored the provirus encoding P210bcr/abl. These results demonstrate that P210bcr/abl expression can induce chronic myelogenous leukemia. Retrovirus-mediated expression of the protein provides a murine model system for further analysis of the disease. | lld:pubmed |
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| pubmed-article:2406902 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2406902 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2406902 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2406902 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2406902 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2406902 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2406902 | pubmed:author | pubmed-author:BaltimoreDD | lld:pubmed |
| pubmed-article:2406902 | pubmed:author | pubmed-author:Van EttenR... | lld:pubmed |
| pubmed-article:2406902 | pubmed:author | pubmed-author:DaleyG QGQ | lld:pubmed |
| pubmed-article:2406902 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2406902 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:2406902 | pubmed:volume | 247 | lld:pubmed |
| pubmed-article:2406902 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2406902 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2406902 | pubmed:pagination | 824-30 | lld:pubmed |
| pubmed-article:2406902 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2406902 | pubmed:meshHeading | pubmed-meshheading:2406902-... | lld:pubmed |
| pubmed-article:2406902 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2406902 | pubmed:articleTitle | Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. | lld:pubmed |
| pubmed-article:2406902 | pubmed:affiliation | Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142. | lld:pubmed |
| pubmed-article:2406902 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2406902 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2406902 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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