| pubmed-article:2403287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2403287 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2403287 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:2403287 | lifeskim:mentions | umls-concept:C0038515 | lld:lifeskim |
| pubmed-article:2403287 | lifeskim:mentions | umls-concept:C0004048 | lld:lifeskim |
| pubmed-article:2403287 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:2403287 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2403287 | pubmed:dateCreated | 1990-10-23 | lld:pubmed |
| pubmed-article:2403287 | pubmed:abstractText | Pulmonary changes in glutathione (GSH) indicated by the concentration of non-protein sulphydryls showed a decrease of 43% in rats exposed for 5 h per day three times to 500 cm3/m3 (2100 mg/m3) styrene vapour. In these rats, only a marginal decrease was observed in the pulmonary cytochrome P450 oxidative metabolism. Following a single 24-h inhalation exposure to 500 cm3/m3 styrene, the decreases in GSH were 66% in lung but only 16% in liver. On the other hand, a multifold increase in the disposition of thioether compounds was found in urine. Pulmonary cytochrome P450-dependent metabolism was decreased, shown by low residual activities of 7-ethoxyresorufin (less than 20%), 7-ethoxycoumarin (53%) and 7-pentoxyresorufin O-dealkylases (76%). Epoxide hydrolase and GSH S-transferase enzyme activities which catalyze styrene detoxification were not decreased. Styrene exposure (24 h) of acetone-, phenobarbital- or 3-methylcholanthrene-pretreated rats resulted in pulmonary effects different from each other and from those of styrene alone. Acetone potentiated the lung effect and elevated 1.5-fold urine thioether output. Inducer pretreatment seemed to be a factor aggravating styrene toxicity; in effect this was clearest in acetone-induced rats. In general, GSH depletion accompanied by inhibition of cytochrome P450-dependent oxidative drug metabolism were the earliest biochemical lesions manifested in styrene-exposed lung. | lld:pubmed |
| pubmed-article:2403287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2403287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2403287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2403287 | pubmed:issn | 0340-5761 | lld:pubmed |
| pubmed-article:2403287 | pubmed:author | pubmed-author:AitioAA | lld:pubmed |
| pubmed-article:2403287 | pubmed:author | pubmed-author:VainioHH | lld:pubmed |
| pubmed-article:2403287 | pubmed:author | pubmed-author:ElovaaraEE | lld:pubmed |
| pubmed-article:2403287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2403287 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:2403287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2403287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2403287 | pubmed:pagination | 365-9 | lld:pubmed |
| pubmed-article:2403287 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2403287 | pubmed:meshHeading | pubmed-meshheading:2403287-... | lld:pubmed |
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| pubmed-article:2403287 | pubmed:meshHeading | pubmed-meshheading:2403287-... | lld:pubmed |
| pubmed-article:2403287 | pubmed:meshHeading | pubmed-meshheading:2403287-... | lld:pubmed |
| pubmed-article:2403287 | pubmed:meshHeading | pubmed-meshheading:2403287-... | lld:pubmed |
| pubmed-article:2403287 | pubmed:meshHeading | pubmed-meshheading:2403287-... | lld:pubmed |
| pubmed-article:2403287 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2403287 | pubmed:articleTitle | Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats. | lld:pubmed |
| pubmed-article:2403287 | pubmed:affiliation | Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland. | lld:pubmed |
| pubmed-article:2403287 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2403287 | lld:pubmed |
