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pubmed-article:2400915pubmed:abstractTextIn a qualitative electron microscopy study we initially reported that exposure of rats to a standard clinical magnetic resonance imaging (MRI) procedure temporarily increased the blood-brain barrier (BBB) permeability to horseradish peroxidase. In this study, we quantitatively support our initial finding. Rats were injected intracardially with radio-labelled diethylenetriaminepentaacetic acid [( 153Gd]DTPA) in the middle of two sequential 23.2 min MRI exposures. Exposed rats (n = 21) showed significantly greater (29%, P = 0.006) retention of [153 Gd]DTPA than sham-exposed rats (n = 22) 1 h after the end of the last 23.2 min exposure. These findings suggest that magnetic fields may alter BBB permeability.lld:pubmed
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pubmed-article:2400915pubmed:articleTitleMagnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats.lld:pubmed
pubmed-article:2400915pubmed:affiliationDepartment of Nuclear Medicine, St. Joseph's Health Centre, London, Ont., Canada.lld:pubmed
pubmed-article:2400915pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2400915pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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