| pubmed-article:2388048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0019171 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0037140 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0524909 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:2388048 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2388048 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2388048 | pubmed:dateCreated | 1990-9-27 | lld:pubmed |
| pubmed-article:2388048 | pubmed:abstractText | Primary duck hepatocyte (PDH) cultures were established from ducklings congenitally infected with the duck hepatitis B virus (DHBV), plated onto feeder cell layers of irradiated human embryonic lung fibroblasts, and observed for 2 to 3 weeks. This system permitted the survival of the PDH in a differentiated form free of fibroblastic overgrowth for at least 3 weeks. The hepatocytes were shown to contain all the replicative DNA intermediates found during DHBV replication as well as the DHBV structural proteins PRE-S1, PRE-S2, and S of duck hepatitis B surface antigen (DHBsAg). The pool of supercoiled (SC) DHBV DNA increased dramatically from days 10 to 14 postplating. This PDH-feeder cell layer cell culture model provides a convenient system to study the effects of conventional inhibitors of DHBV replication and compounds targeted at the supercoiled form of DHBV DNA. This approach should allow the evaluation of a variety of strategies for treating chronic carriers of hepadnaviruses. | lld:pubmed |
| pubmed-article:2388048 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2388048 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2388048 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2388048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2388048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2388048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2388048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2388048 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2388048 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:WangY YYY | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:GussHH | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:BirchCC | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:BishopNN | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:LocarniniSS | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:CiviticoGG | lld:pubmed |
| pubmed-article:2388048 | pubmed:author | pubmed-author:GuoK JKJ | lld:pubmed |
| pubmed-article:2388048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2388048 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2388048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2388048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2388048 | pubmed:pagination | 82-9 | lld:pubmed |
| pubmed-article:2388048 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2388048 | pubmed:meshHeading | pubmed-meshheading:2388048-... | lld:pubmed |
| pubmed-article:2388048 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2388048 | pubmed:articleTitle | Antiviral strategies in chronic hepatitis B virus infection: I. Establishment of an in vitro system using the duck hepatitis B virus model. | lld:pubmed |
| pubmed-article:2388048 | pubmed:affiliation | Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:2388048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2388048 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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