| pubmed-article:2387267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C0008046 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C0242290 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2387267 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2387267 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2387267 | pubmed:dateCreated | 1990-9-21 | lld:pubmed |
| pubmed-article:2387267 | pubmed:abstractText | A definition of the role of IGF-I in differentiation and development requires a detailed understanding of its expression and tissue-specific regulation in embryogenesis. Standard techniques for analysis of IGF-I gene expression are not sufficiently sensitive for studies in early embryos. We have used the highly sensitive polymerase chain reaction (PCR) to study IGF-I gene expression in whole chick embryos from the late blastula stage (E0 = laying) through the end of organogenesis (day 8), and in liver, brain and pancreas during mid-late embryogenesis and perinatally (hatching = day 21). Although at low levels in the blastoderm and gastrula, IGF-I mRNA was detectable in the whole embryo in all stages studied, with a tendency of the signal to increase with age during the first week of embryogenesis. In mid- and late embryogenesis, we easily detected IGF-I mRNA transcripts in pancreas and brain while the levels in the liver were barely detectable. Liver IGF-I mRNA increased markedly at the peak of postnatal growth (day 50). These studies suggest that while the major source of postnatal IGF-I may be the liver, extrahepatic tissues may be the predominant source of IGF-I during prenatal chicken development. | lld:pubmed |
| pubmed-article:2387267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2387267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2387267 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2387267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2387267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2387267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2387267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2387267 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2387267 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:2387267 | pubmed:author | pubmed-author:SerranoJJ | lld:pubmed |
| pubmed-article:2387267 | pubmed:author | pubmed-author:LeRoithDD | lld:pubmed |
| pubmed-article:2387267 | pubmed:author | pubmed-author:RobertsC... | lld:pubmed |
| pubmed-article:2387267 | pubmed:author | pubmed-author:de PabloFF | lld:pubmed |
| pubmed-article:2387267 | pubmed:author | pubmed-author:ShuldinerA... | lld:pubmed |
| pubmed-article:2387267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2387267 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:2387267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2387267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2387267 | pubmed:pagination | 1547-9 | lld:pubmed |
| pubmed-article:2387267 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:meshHeading | pubmed-meshheading:2387267-... | lld:pubmed |
| pubmed-article:2387267 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2387267 | pubmed:articleTitle | The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis. | lld:pubmed |
| pubmed-article:2387267 | pubmed:affiliation | Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:2387267 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2387267 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2387267 | lld:pubmed |
