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pubmed-article:2384007pubmed:abstractTextExperimental autoimmune uveoretinitis (EAU), induced in (LEW X BN) F1 rats by immunization with S antigen (S-Ag) is T cell and antibody (ab) mediated and anti-S-Ag IgE ab have been involved in the occurrence of ocular lesions. (LEW X BN) F1 rats repeatedly injected with HgCl2 develop an autoimmune disease characterized by numerous auto-ab and a high increase of serum IgE level. We hypothesize that large amounts of non anti-S-Ag IgE induced by HgCl2 would compete with anti-S-Ag induced by S-Ag immunization so as to prevent EAU to occur. Indeed (LEW X BN) F1 rats immunized with S-Ag 7 days after the first HgCl2 injection are strongly protected against EAU. The putative role of the different mercury-induced autoimmune phenomena in the protection against EAU are discussed.lld:pubmed
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pubmed-article:2384007pubmed:pagination135-8lld:pubmed
pubmed-article:2384007pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2384007pubmed:year1990lld:pubmed
pubmed-article:2384007pubmed:articleTitleInhibition of experimental autoimmune uveoretinitis by mercuric chloride injections in (Lewis x Brown Norway) F1 hybrid rats.lld:pubmed
pubmed-article:2384007pubmed:affiliationPathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France.lld:pubmed
pubmed-article:2384007pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2384007pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed