Linked Life Data

2380393

Source:http://linkedlifedata.com/resource/pubmed/id/2380393

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:2380393rdf:typepubmed:Citationlld:pubmed
pubmed-article:2380393lifeskim:mentionsumls-concept:C0030705lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C2349001lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C0025663lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C0681850lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C1706203lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C2697811lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C0227349lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C0009375lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C0205307lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C1441616lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C1550501lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C1521828lld:lifeskim
pubmed-article:2380393lifeskim:mentionsumls-concept:C1514485lld:lifeskim
pubmed-article:2380393pubmed:issue6lld:pubmed
pubmed-article:2380393pubmed:dateCreated1990-9-11lld:pubmed
pubmed-article:2380393pubmed:abstractTextAn increased colonic epithelial proliferation rate and an increase of the cryptal proliferative zone are probable markers of increased susceptibility to colonic cancer. In this study an immunohistochemical method using 5-bromo-deoxyuridine (BrdUrd) to measure the proliferation rate of colonic mucosa in vitro was used. Fresh endoscopic colonic biopsy specimens were incubated with BrdUrd and then processed for immunohistochemistry using a monoclonal antibody. Essential procedures with respect to the equal distribution of nuclei stained with BrdUrd in the biopsy specimens proved to be the cutting of the specimens before incubation and the use of a microwave oven at the beginning of incubation. The use of the procedure of the running average showed that 12 length cut crypts are sufficient to determine reliably the proliferation rate, expressed as the labelling index (LI). This was determined in the biopsy specimens of 10 subjects without organic colonic disease, eight patients with adenomatous colonic polyps, and in six patients with (recent) colonic carcinoma. Mean LI in the controls was significantly lower than in patients with colonic polyps and in those with colon cancer. It is concluded that this method is promising for screening persons at risk for colon cancer and will be of great potential in performing dietary intervention studies in these subjects.lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:languageenglld:pubmed
pubmed-article:2380393pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:citationSubsetAIMlld:pubmed
pubmed-article:2380393pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2380393pubmed:statusMEDLINElld:pubmed
pubmed-article:2380393pubmed:monthJunlld:pubmed
pubmed-article:2380393pubmed:issn0021-9746lld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:MulderN HNHlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:HardonkM JMJlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:KoudstaalJJlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:HarmsGGlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:GrondJJlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:de VriesE GEGlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:KleibeukerJ...lld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:WelbergJ WJWlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:de LeyLLlld:pubmed
pubmed-article:2380393pubmed:authorpubmed-author:ZwartNNlld:pubmed
pubmed-article:2380393pubmed:issnTypePrintlld:pubmed
pubmed-article:2380393pubmed:volume43lld:pubmed
pubmed-article:2380393pubmed:ownerNLMlld:pubmed
pubmed-article:2380393pubmed:authorsCompleteYlld:pubmed
pubmed-article:2380393pubmed:pagination453-6lld:pubmed
pubmed-article:2380393pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:meshHeadingpubmed-meshheading:2380393-...lld:pubmed
pubmed-article:2380393pubmed:year1990lld:pubmed
pubmed-article:2380393pubmed:articleTitleProliferation rate of colonic mucosa in normal subjects and patients with colonic neoplasms: a refined immunohistochemical method.lld:pubmed
pubmed-article:2380393pubmed:affiliationDepartment of Medical Oncology, University Hospital, Groningen, The Netherlands.lld:pubmed
pubmed-article:2380393pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2380393pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:2380393pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2380393lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2380393lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2380393lld:pubmed