| pubmed-article:2371282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0079870 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0001924 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:2371282 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:2371282 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:2371282 | pubmed:dateCreated | 1990-8-23 | lld:pubmed |
| pubmed-article:2371282 | pubmed:abstractText | A method based on the polymerase chain reaction is described for constructing a clustered set of basepair changes, deletions, or insertions at any site on a DNA fragment. Advantages of the procedure are that virtually every product has the desired sequence alteration and that only a single round of polymerase chain reaction is required. We used this method to demonstrate that the binding of a specific liver nuclear protein, which we call eH-TF, is essential for the function of the enhancer of the mouse albumin gene. The eH-TF binding activity is hepatocyte-specific; it binds to a functional region of the albumin promoter and is distinct from other albumin promoter factors, and part of the eH-TF binding sequence, TGTTTGC, occurs in functional regulatory sites of other liver-specific genes. | lld:pubmed |
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| pubmed-article:2371282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2371282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2371282 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2371282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2371282 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2371282 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2371282 | pubmed:author | pubmed-author:LimJ SJS | lld:pubmed |
| pubmed-article:2371282 | pubmed:author | pubmed-author:ZaretK SKS | lld:pubmed |
| pubmed-article:2371282 | pubmed:author | pubmed-author:DiPersioC MCM | lld:pubmed |
| pubmed-article:2371282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2371282 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:2371282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2371282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2371282 | pubmed:pagination | 5469-73 | lld:pubmed |
| pubmed-article:2371282 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2371282 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2371282 | pubmed:articleTitle | Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer. | lld:pubmed |
| pubmed-article:2371282 | pubmed:affiliation | Section of Biochemistry, Brown University, Providence, RI 02912. | lld:pubmed |
| pubmed-article:2371282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2371282 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2371282 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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