pubmed-article:2355913 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0007284 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0005186 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:2355913 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:2355913 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:2355913 | pubmed:dateCreated | 1990-7-20 | lld:pubmed |
pubmed-article:2355913 | pubmed:abstractText | Regulatory regions of the beta-actin gene of the common carp (Cyprinus carpio) have been examined by linking upstream, 5'-flanking sequences and regions of the first intron to a bacterial chloramphenicol acetyltransferase (CAT) reporter gene. By analysis of the mRNA products and encoded CAT activity, we have identified four putative regions that influence expression: (i) a negative regulatory region 2,300 to 1,100 base pairs (bp) ahead of the gene; (ii) a proximal promoter element, containing the highly conserved CCAAT, CC(A/T)6GG, and TATA boxes, that is within the first 204 bp upstream of the initiation site; (iii) a negative element of 426 bp in the 5' region of the first intron; and (iv) a positive 304-bp element near the end of the first intron that contains highly conserved sequences found in all characterized beta-actin genes. The positive intron element is not a classical enhancer; it is position and orientation dependent, as has been observed in other housekeeping genes in vertebrates. Depending on the elements joined together, CAT gene expression can be modulated more than 500-fold in transfected mouse cells. | lld:pubmed |
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pubmed-article:2355913 | pubmed:language | eng | lld:pubmed |
pubmed-article:2355913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2355913 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2355913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2355913 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2355913 | pubmed:month | Jul | lld:pubmed |
pubmed-article:2355913 | pubmed:issn | 0270-7306 | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:MoavBB | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:FarasA JAJ | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:LinZ SZS | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:HackettP BPB | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:GuiseK SKS | lld:pubmed |
pubmed-article:2355913 | pubmed:author | pubmed-author:KapuscinskiA... | lld:pubmed |
pubmed-article:2355913 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2355913 | pubmed:volume | 10 | lld:pubmed |
pubmed-article:2355913 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2355913 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2355913 | pubmed:pagination | 3432-40 | lld:pubmed |
pubmed-article:2355913 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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