| pubmed-article:2352421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2352421 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:2352421 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2352421 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2352421 | pubmed:dateCreated | 1990-7-13 | lld:pubmed |
| pubmed-article:2352421 | pubmed:abstractText | T-cell depletion leads to impaired wound healing. We studied the effect of combined T-helper and T-suppressor lymphocyte depletion on wound healing and compared it with the effect of all T-cell depletion. Groups of 10 male balb/c mice, 8 weeks old, underwent a 2.5-cm skin incision and subcutaneous implantation of polyvinyl alcohol sponges. Twenty-four hours prior to wounding one group was treated with 3OH12, a rat anti-mouse monoclonal antibody against the Thy-1.2 antigen present on all T-cells (1 mg); another group received 1 mg each of GK1.5 (anti-L3T4, CD4; anti-helper/effector subset) and 2.43 (anti-Lyt 2.1, CD8; anti-suppressor/cytotoxic subset). All monoclonal antibodies are cytotoxic in vivo. Controls received 1 mg of nonspecific rat IgG. Treatments were repeated weekly. Animals were sacrificed at 2 and 4 weeks postwounding. Equal depletion of all T- and Th- and Ts-subsets in peripheral blood and spleens was noted in the two experimental groups at sacrifice. Depleting Thy-1.2 cells (all T-cells) impaired wound healing as assessed by wound breaking strength and collagen synthesis. Combined anti-T-helper/effector and T-suppressor/cytotoxic depletion resulted in improved wound-healing parameters. This suggests that there is a Thy-1.2+, L3T4-, Lyt2- subpopulation of T lymphocytes which normally stimulates wound healing. | lld:pubmed |
| pubmed-article:2352421 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2352421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2352421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2352421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2352421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2352421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2352421 | pubmed:month | May | lld:pubmed |
| pubmed-article:2352421 | pubmed:issn | 0022-4804 | lld:pubmed |
| pubmed-article:2352421 | pubmed:author | pubmed-author:FrankelH LHL | lld:pubmed |
| pubmed-article:2352421 | pubmed:author | pubmed-author:WasserkrugH... | lld:pubmed |
| pubmed-article:2352421 | pubmed:author | pubmed-author:BarbulAA | lld:pubmed |
| pubmed-article:2352421 | pubmed:author | pubmed-author:LazarouS ASA | lld:pubmed |
| pubmed-article:2352421 | pubmed:author | pubmed-author:EfronJ EJE | lld:pubmed |
| pubmed-article:2352421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2352421 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:2352421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2352421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2352421 | pubmed:pagination | 460-3 | lld:pubmed |
| pubmed-article:2352421 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:meshHeading | pubmed-meshheading:2352421-... | lld:pubmed |
| pubmed-article:2352421 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2352421 | pubmed:articleTitle | Wound healing and T-lymphocytes. | lld:pubmed |
| pubmed-article:2352421 | pubmed:affiliation | Department of Surgery, Sinai Hospital of Baltimore, Maryland 21215. | lld:pubmed |
| pubmed-article:2352421 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2352421 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2352421 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2352421 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2352421 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2352421 | lld:pubmed |
