| pubmed-article:2345133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C0162570 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C0080331 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C0018837 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C1705167 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:2345133 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:2345133 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2345133 | pubmed:dateCreated | 1990-7-3 | lld:pubmed |
| pubmed-article:2345133 | pubmed:abstractText | Extracellular nonreplicating bacteriophage T4 particles accumulate mutations as functions of temperature, time, pH, and ionic environment via two mechanisms: 5-hydroxymethylcytidine deamination produces G.C----A.T transitions while a guanosine modification produces transversions. Neither frameshift mutations nor mutations at A.T base pairs are appreciably induced. We now show that heat induces G.C----T.A transversions which we suggest may arise via a G*.A mispair, in which G* is a modified guanosine that has experienced a glycosylic bond migration. The rate of this reaction at 37 degrees C is sufficient to present a genetic hazard, particularly to large genomes; thus, the lesion is probably efficiently repaired in cellular genomes. | lld:pubmed |
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| pubmed-article:2345133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2345133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2345133 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2345133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2345133 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2345133 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:2345133 | pubmed:author | pubmed-author:DrakeJ WJW | lld:pubmed |
| pubmed-article:2345133 | pubmed:author | pubmed-author:KrickerM CMC | lld:pubmed |
| pubmed-article:2345133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2345133 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:2345133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2345133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2345133 | pubmed:pagination | 3037-9 | lld:pubmed |
| pubmed-article:2345133 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2345133 | pubmed:meshHeading | pubmed-meshheading:2345133-... | lld:pubmed |
| pubmed-article:2345133 | pubmed:meshHeading | pubmed-meshheading:2345133-... | lld:pubmed |
| pubmed-article:2345133 | pubmed:meshHeading | pubmed-meshheading:2345133-... | lld:pubmed |
| pubmed-article:2345133 | pubmed:meshHeading | pubmed-meshheading:2345133-... | lld:pubmed |
| pubmed-article:2345133 | pubmed:meshHeading | pubmed-meshheading:2345133-... | lld:pubmed |
| pubmed-article:2345133 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2345133 | pubmed:articleTitle | Heat mutagenesis in bacteriophage T4: another walk down the transversion pathway. | lld:pubmed |
| pubmed-article:2345133 | pubmed:affiliation | Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. | lld:pubmed |
| pubmed-article:2345133 | pubmed:publicationType | Journal Article | lld:pubmed |
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