| pubmed-article:2344924 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0041623 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0229525 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0043515 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C2827068 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0023693 | lld:lifeskim |
| pubmed-article:2344924 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:2344924 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2344924 | pubmed:dateCreated | 1990-7-5 | lld:pubmed |
| pubmed-article:2344924 | pubmed:abstractText | The endocrine cells of the oxyntic mucosa of five patients with longstanding Zollinger-Ellison syndrome were quantitatively investigated with electron microscopy and two light microscopic methods (Grimelius and immunostaining for chromogranin A). Ultrastructurally, the volume density of endocrine cells was 3.2% +/- 1.1% of the mucosal epithelial component, a 168% increase (P less than 0.001) over the value found in normal subjects. Of the six endocrine cell types of human oxyntic mucosa, only enterochromaffinlike cells increased in cell density (65% +/- 15% of the total endocrine cell mass), size, and number of cell profiles per unit area. The enterochromaffinlike cells also underwent morphological changes of secretory granules with a decrease in vacuolated forms, increase in elongated profiles, and appearance of granules with a punctate structure of the core. The latter variety of granules was previously observed only in carcinoid tumors of the oxyntic mucosa and is possibly related to the enterochromaffinlike cell hyperplasia-neoplasia sequence seen in hypergastrinemic patients. A positive relationship was found between endocrine cell densities evaluated ultrastructurally and with chromogranin A immunostaining. It is concluded that in Zollinger-Ellison syndrome, the trophic effects induced by longstanding hypergastrinemia are strictly selective for enterochromaffinlike cells and are associated with ultrastructural features typical for enterochromaffinlike cell tumors. | lld:pubmed |
| pubmed-article:2344924 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2344924 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2344924 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2344924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2344924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2344924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2344924 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2344924 | pubmed:issn | 0016-5085 | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:BordiCC | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:Delle FaveGG | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:RobuttiFF | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:D'AddaTT | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:BaggiM TMT | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:PilatoF PFP | lld:pubmed |
| pubmed-article:2344924 | pubmed:author | pubmed-author:CorletoVV | lld:pubmed |
| pubmed-article:2344924 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2344924 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:2344924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2344924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2344924 | pubmed:pagination | 17-26 | lld:pubmed |
| pubmed-article:2344924 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2344924 | pubmed:meshHeading | pubmed-meshheading:2344924-... | lld:pubmed |
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| pubmed-article:2344924 | pubmed:meshHeading | pubmed-meshheading:2344924-... | lld:pubmed |
| pubmed-article:2344924 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2344924 | pubmed:articleTitle | Quantitative ultrastructure of endocrine cells of oxyntic mucosa in Zollinger-Ellison syndrome. Correspondence with light microscopic findings. | lld:pubmed |
| pubmed-article:2344924 | pubmed:affiliation | Institute of Pathological Anatomy, University of Parma, Italy. | lld:pubmed |
| pubmed-article:2344924 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2344924 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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