| pubmed-article:2341718 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0017526 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0376152 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:2341718 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:2341718 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2341718 | pubmed:dateCreated | 1990-6-28 | lld:pubmed |
| pubmed-article:2341718 | pubmed:abstractText | IL-6 enhances the differentiation of pluripotent hematopoietic stem cells but predominantly affects the differentiation of hematopoietic cells in the granulocyte-macrophage lineage. We have previously shown that multinucleated cells (MNC) with many features of the osteoclast phenotype form in long term human marrow cultures. Addition of rhIL-6 (10 to 100 pg/ml) to these cultures significantly increased MNC formation, with greater than 80% of the MNC expressing an Ag that cross-reacts with the mAb 23c6. This antibody preferentially binds to osteoclasts. rhIL-6 did not enhance MNC formation in marrow cultures treated with 1,25 dihydroxyvitamin D3, a potent stimulator of MNC formation, but significantly increased the percentage of MNC that cross-reacted with the 23c6 mAb. Addition of antihuman IL-1 to cultures treated with rhIL-6 totally inhibited the increase in MNC formation stimulated by rhIL-6. In contrast, anti-IL-1 did not affect MNC formation stimulated by 1,25 dihydroxyvitamin D3. Further, conditioned media from marrow cultures exposed to rhIL-6 contained elevated levels of IL-1 beta (500 pg/ml compared to 23 pg/ml in control cultures 15 h after IL-6 addition). These results suggest that the capacity of rhIL-6 to stimulate formation of MNC which cross-react with 23c6 is mediated by induction of release of IL-1 beta. | lld:pubmed |
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| pubmed-article:2341718 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2341718 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341718 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2341718 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2341718 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2341718 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2341718 | pubmed:author | pubmed-author:KuriharaNN | lld:pubmed |
| pubmed-article:2341718 | pubmed:author | pubmed-author:BertoliniDD | lld:pubmed |
| pubmed-article:2341718 | pubmed:author | pubmed-author:SudaTT | lld:pubmed |
| pubmed-article:2341718 | pubmed:author | pubmed-author:AkiyamaYY | lld:pubmed |
| pubmed-article:2341718 | pubmed:author | pubmed-author:RoodmanG DGD | lld:pubmed |
| pubmed-article:2341718 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2341718 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2341718 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:2341718 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2341718 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2341718 | pubmed:pagination | 4226-30 | lld:pubmed |
| pubmed-article:2341718 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2341718 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2341718 | pubmed:articleTitle | IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. | lld:pubmed |
| pubmed-article:2341718 | pubmed:affiliation | Research Service, Audie Murphy VA Hospital, San Antonio, TX 78284. | lld:pubmed |
| pubmed-article:2341718 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2341718 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2341718 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2341718 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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