| pubmed-article:233906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0030551 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0003962 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C1553423 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:233906 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:233906 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:233906 | pubmed:dateCreated | 1993-7-22 | lld:pubmed |
| pubmed-article:233906 | pubmed:abstractText | Thymus-dependent (T) lymphocytes from (2 x 13)F1 hybrid guinea pigs immunized to ovalbumin (OVA) in complete Freund's adjuvant can be stimulated to proliferate in vitro by antigen-pulsed peritoneal exudate cells (PECs) derived from either strain 2 or strain 13 donors. In this communication, we show that the population of primed F1 T lymphocytes which can be activated by antigen-pulsed strain 2 PECs is largely independent of the population of cells that can be activated by antigen-pulsed strain 13 PECs. This was demonstrated by both positive and negative selection procedures. In the former, T lymphocytes from OVA-primed (2 x 13)F1 donors were enriched by initial culture with OVA-pulsed strain 2 or strain 13 PECs for 1 wk. Cells selected by culture with OVA-pulsed strain 2 PECs responded well to OVA-pulsed strain 2 PECs and poorly to OVA-pulsed strain 13 PECs. If positive selection had been carried out with OVA-pulsed strain 13 PECs, the selected F1 T cells responded well to OVA-pulsed 13 PECs and poorly to OVA-pulsed 2 PECs. Negative selection was achieved by short term culture with antigen-pulsed PECs and by eliminating proliferating cells by treatment with bromodeoxyuridine and light. This procedure demonstrated that the population of primed F1 T lymphocytes which are responsive to OVA or to purified protein derivative of tuberculin can be divided into subpopulations uniquely responsive to antigen on either strain 2 or strain 13 PECs. Evidence was presented to indicate that this selective responsiveness was not the result of the action of alloantigen-specific suppressor cells. The results are considered in terms of current concepts of the genetic and molecular regulation of the interaction of PECs and T lymphocytes. | lld:pubmed |
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| pubmed-article:233906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:233906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:233906 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:233906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:233906 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:233906 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:233906 | pubmed:author | pubmed-author:RosenthalA... | lld:pubmed |
| pubmed-article:233906 | pubmed:author | pubmed-author:PaulW EWE | lld:pubmed |
| pubmed-article:233906 | pubmed:author | pubmed-author:ShevachE MEM | lld:pubmed |
| pubmed-article:233906 | pubmed:author | pubmed-author:ThomasD WDW | lld:pubmed |
| pubmed-article:233906 | pubmed:author | pubmed-author:PickeralSS | lld:pubmed |
| pubmed-article:233906 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:233906 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:233906 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:233906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:233906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:233906 | pubmed:pagination | 618-30 | lld:pubmed |
| pubmed-article:233906 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:233906 | pubmed:meshHeading | pubmed-meshheading:233906-T... | lld:pubmed |
| pubmed-article:233906 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:233906 | pubmed:articleTitle | Independent populations of primed F1 guinea pig T lymphocytes respond to antigen-pulsed parental peritoneal exudate cells. | lld:pubmed |
| pubmed-article:233906 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014. | lld:pubmed |
| pubmed-article:233906 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:233906 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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