| pubmed-article:2333388 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C1283994 | lld:lifeskim |
| pubmed-article:2333388 | lifeskim:mentions | umls-concept:C1706778 | lld:lifeskim |
| pubmed-article:2333388 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2333388 | pubmed:dateCreated | 1990-6-6 | lld:pubmed |
| pubmed-article:2333388 | pubmed:abstractText | The allocation of cells to the inner cell mass (ICM) and trophectoderm (TE) was investigated at 6-h intervals from 78 h to 102 h after hCG injection in 3/4 mouse embryos to determine the effect of removal of a single blastomere at the 4-cell stage on early differentiation. The procedures used to produce 3/4 embryos had little effect on embryo development. Embryos that had a single blastomere removed and then re-aggregated (RA embryos) had the same total number of cells as untreated (UT) embryos except at 78 h (P less than 0.05) and 102 h (P less than 0.01) post hCG where there were slightly less cells in RA embryos. Three-quarter embryos always had significantly fewer cells than RA embryos (P less than 0.001), with an average of 74% of the total cell number of RA embryos. As expected, 3/4 embryos always had significantly fewer cells in the ICM and TE compared with RA embryos (P less than 0.001). However, the ICM:TE ratio was also significantly lower in 3/4 embryos compared with RA embryos at 84, 96, and 102 h post hCG, indicating that the allocation of cells to the ICM and TE was disturbed. The ICM:TE ratio of 3/4 embryos could not be manipulated if either an early- or late-dividing blastomere was selectively biopsied at the 4-cell stage; this suggests that the known preferential contribution of an early-dividing blastomere to the ICM is not cell autonomous. | lld:pubmed |
| pubmed-article:2333388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2333388 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2333388 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2333388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2333388 | pubmed:issn | 1031-3613 | lld:pubmed |
| pubmed-article:2333388 | pubmed:author | pubmed-author:TrounsonA OAO | lld:pubmed |
| pubmed-article:2333388 | pubmed:author | pubmed-author:WiltonL JLJ | lld:pubmed |
| pubmed-article:2333388 | pubmed:author | pubmed-author:SomersG RGR | lld:pubmed |
| pubmed-article:2333388 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2333388 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2333388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2333388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2333388 | pubmed:pagination | 51-9 | lld:pubmed |
| pubmed-article:2333388 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:meshHeading | pubmed-meshheading:2333388-... | lld:pubmed |
| pubmed-article:2333388 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2333388 | pubmed:articleTitle | Allocation of cells to the inner cell mass and trophectoderm of 3/4 mouse embryos. | lld:pubmed |
| pubmed-article:2333388 | pubmed:affiliation | Centre for Early Human Development, Monash Medical Centre, Clayton, Victoria, Australia. | lld:pubmed |
| pubmed-article:2333388 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2333388 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
