| pubmed-article:2333290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2333290 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2333290 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2333290 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:2333290 | lifeskim:mentions | umls-concept:C1742737 | lld:lifeskim |
| pubmed-article:2333290 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:2333290 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2333290 | pubmed:dateCreated | 1990-6-6 | lld:pubmed |
| pubmed-article:2333290 | pubmed:abstractText | We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbumin, has been covalently linked to the small DNA-binding protein protamine or to polylysines of various sizes through a disulfide linkage. These modified transferrin molecules maintain their ability to bind their cognate receptor and to mediate efficient iron transport into the cell. The transferrin-polycation molecules form electrophoretically stable complexes with double-stranded DNA, single-stranded DNA, and modified RNA molecules independent of nucleic acid size (from short oligonucleotides to DNA of 21 kilobase pairs). When complexes of transferrin-polycation and a bacterial plasmid DNA containing the gene for Photinus pyralis luciferase are supplied to eukaryotic cells, high-level expression of the luciferase gene occurs, demonstrating transferrin receptor-mediated endocytosis and expression of the imported DNA. We refer to this delivery system as "transferrinfection." | lld:pubmed |
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| pubmed-article:2333290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2333290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2333290 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2333290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2333290 | pubmed:month | May | lld:pubmed |
| pubmed-article:2333290 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2333290 | pubmed:author | pubmed-author:BirnstielM... | lld:pubmed |
| pubmed-article:2333290 | pubmed:author | pubmed-author:BeugHH | lld:pubmed |
| pubmed-article:2333290 | pubmed:author | pubmed-author:WagnerEE | lld:pubmed |
| pubmed-article:2333290 | pubmed:author | pubmed-author:ZenkeMM | lld:pubmed |
| pubmed-article:2333290 | pubmed:author | pubmed-author:CotterAA | lld:pubmed |
| pubmed-article:2333290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2333290 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:2333290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2333290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2333290 | pubmed:pagination | 3410-4 | lld:pubmed |
| pubmed-article:2333290 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2333290 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2333290 | pubmed:articleTitle | Transferrin-polycation conjugates as carriers for DNA uptake into cells. | lld:pubmed |
| pubmed-article:2333290 | pubmed:affiliation | Research Institute of Molecular Pathology, Vienna, Austria. | lld:pubmed |
| pubmed-article:2333290 | pubmed:publicationType | Journal Article | lld:pubmed |
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