| pubmed-article:2331524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0019638 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0008625 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0085415 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0683325 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2331524 | lifeskim:mentions | umls-concept:C0027523 | lld:lifeskim |
| pubmed-article:2331524 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2331524 | pubmed:dateCreated | 1990-6-6 | lld:pubmed |
| pubmed-article:2331524 | pubmed:abstractText | We describe the chromosomal abnormalities found in 104 previously untreated patients with non-Hodgkin's lymphoma (NHL) and the correlations of these abnormalities with disease characteristics. The cytogenetic method used was a 24- to 48-hour culture, followed by G-banding. Several significant associations were discovered. A trisomy 3 was correlated with high-grade NHL. In the patients with an immunoblastic NHL, an abnormal chromosome no. 3 or 6 was found significantly more frequently. As previously described, a t(14;18) was significantly correlated with a follicular growth pattern. Abnormalities on chromosome no. 17 were correlated with a diffuse histology and a shorter survival. A shorter survival was also correlated with a +5, +6, +18, all abnormalities on chromosome no. 5, or involvement of breakpoint 14q11-12. In a multivariate analysis, these chromosomal abnormalities appeared to be independent prognostic factors and correlated with survival more strongly than any traditional prognostic variable. Patients with a t(11;14)(q13;q32) had an elevated lactate dehydrogenase (LDH). Skin infiltration was correlated with abnormalities on 2p. Abnormalities involving breakpoints 6q11-16 were correlated with B symptoms. Patients with abnormalities involving breakpoints 3q21-25 and 13q21-24 had more frequent bulky disease. The correlations of certain clinical findings with specific chromosomal abnormalities might help unveil the pathogenetic mechanisms of NHL and tailor treatment regimens. | lld:pubmed |
| pubmed-article:2331524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2331524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2331524 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2331524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2331524 | pubmed:month | May | lld:pubmed |
| pubmed-article:2331524 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:2331524 | pubmed:author | pubmed-author:AndersonJJ | lld:pubmed |
| pubmed-article:2331524 | pubmed:author | pubmed-author:SangerW GWG | lld:pubmed |
| pubmed-article:2331524 | pubmed:author | pubmed-author:ArmitageJ OJO | lld:pubmed |
| pubmed-article:2331524 | pubmed:author | pubmed-author:WeisenburgerD... | lld:pubmed |
| pubmed-article:2331524 | pubmed:author | pubmed-author:SchoutenH CHC | lld:pubmed |
| pubmed-article:2331524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2331524 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2331524 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:2331524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2331524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2331524 | pubmed:pagination | 1841-7 | lld:pubmed |
| pubmed-article:2331524 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:meshHeading | pubmed-meshheading:2331524-... | lld:pubmed |
| pubmed-article:2331524 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2331524 | pubmed:articleTitle | Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome. The Nebraska Lymphoma Study Group. | lld:pubmed |
| pubmed-article:2331524 | pubmed:affiliation | Department of Internal Medicine, University of Nebraska Medical Center, Omaha. | lld:pubmed |
| pubmed-article:2331524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2331524 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2331524 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2331524 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2331524 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2331524 | lld:pubmed |
