| pubmed-article:2328404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2328404 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2328404 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2328404 | pubmed:dateCreated | 1990-5-30 | lld:pubmed |
| pubmed-article:2328404 | pubmed:abstractText | 1. The effect of L-NG-nitro arginine (L-NOARG) was compared with that of L-NG-monomethyl arginine (L-NMMA) on vasodilatation of the isolated aorta of the rabbit and perfused mesentery of the rat in response to acetylcholine (ACh) and sodium nitroprusside (NP). 2. L-NOARG (1.5-100 microM) and L-NMMA (3-100 microM) produced concentration-related contraction of the rabbit aorta precontracted with phenylephrine (700-900 nM). Similarly, L-NOARG (10-200 microM) and L-NMMA (30-100 microM) elevated perfusion pressure of the noradrenaline (NA, 0.6-2.5 mM)-preconstricted rat mesentery preparation. 3. L-NOARG (1.5-100 microM) and L-NMMA (3-100 microM) caused concentration-related inhibition of the vasodilator effect of ACh (0.01-1.0 microM) on the rabbit aorta without influencing responses to NP (0.03-0.5 microM). L-NOARG methyl ester (30 microM) also inhibited ACh-induced vasorelaxation with similar potency to NOARG. L-arginine (30-150 microM) but not D-arginine (100 microM) caused graded reversal of the inhibitory effect of both L-NOARG (15 microM) and L-NMMA (30 microM). Complete reversal of the effect of both inhibitors was achieved with 150 microM L-arginine. L-Alanine (50 microM), L-arginosuccinic acid (5 microM), L-citrulline (50 microM), L-methionine (50 microM) and L-ornithine (50 microM) failed to reverse the inhibitory effect of L-NOARG (15 microM). 4. L-NOARG (10-200 microM) and L-NMMA (30-100 microM) inhibited the vasodilator effect of ACh (0.006-18.0 nmol) in the rat mesentery without affecting vasodilatation due to NP (1.1-11.1 nmol). L-Arginine (100 microM) but not D-arginine (100 microM) produced partial reversal of the effect of L-NOARG (30 microM) and L-NMMA (30 microM). 5. L- and D-N'-butyloxycarbonyl No-nitro arginine (100 microM) produced modest (approximately 20%) inhibition of the effect of ACh on the rabbit aorta; this effect was not reversible with L-arginine (100 microM). L-Namonocarbobenzoxy arginine (L-NMCA, 5O microM), L-N-NG-dicarbobenzoxy arginine (L-NDCA, 5 microM) and L-NG-tosyl arginine (50 microM) were inactive. 6. These results identify L-NOARG as a potent, L-arginine reversible inhibitor of endothelium-dependent vasodilatation. The available data suggests that L-NOARG, like L-NMMA, inhibits endothelial nitric oxide (NO) biosynthesis. | lld:pubmed |
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| pubmed-article:2328404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2328404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2328404 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2328404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2328404 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2328404 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2328404 | pubmed:author | pubmed-author:GibsonAA | lld:pubmed |
| pubmed-article:2328404 | pubmed:author | pubmed-author:MooreP KPK | lld:pubmed |
| pubmed-article:2328404 | pubmed:author | pubmed-author:EvansR ARA | lld:pubmed |
| pubmed-article:2328404 | pubmed:author | pubmed-author:ChongN WNW | lld:pubmed |
| pubmed-article:2328404 | pubmed:author | pubmed-author:al-SwayehO... | lld:pubmed |
| pubmed-article:2328404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2328404 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:2328404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2328404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2328404 | pubmed:pagination | 408-12 | lld:pubmed |
| pubmed-article:2328404 | pubmed:dateRevised | 2010-3-22 | lld:pubmed |
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| pubmed-article:2328404 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2328404 | pubmed:articleTitle | L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. | lld:pubmed |
| pubmed-article:2328404 | pubmed:affiliation | Biomedical Sciences Division, King's College London. | lld:pubmed |
| pubmed-article:2328404 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2328404 | pubmed:publicationType | In Vitro | lld:pubmed |
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