| pubmed-article:2317927 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C1519941 | lld:lifeskim |
| pubmed-article:2317927 | lifeskim:mentions | umls-concept:C0079809 | lld:lifeskim |
| pubmed-article:2317927 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2317927 | pubmed:dateCreated | 1990-5-2 | lld:pubmed |
| pubmed-article:2317927 | pubmed:abstractText | We have assessed the validity of using platelet-rich plasma (PRP) to measure dopamine uptake by platelets. In addition, we report on a pilot study comparing [3H]dopamine uptake by PRP from psychotic patients to that by PRP from healthy volunteers. Uptake of radiolabelled dopamine by PRP was related to the concentration of [3H]dopamine added and correlated with platelet number. [3H]dopamine uptake by PRP was not altered by varying pH (6.8 to 8.0) or by the time PRP was incubated prior to the addition of the radiolabelled dopamine. 11.7 +/- 0.34% (mean +/- SEM) of [3H]dopamine added to plasma was precipitated by polyethylene glycol (PEG) and appeared to be associated with a large molecular mass component of plasma. The amount of PEG precipitable [3H]dopamine did not correlate with dopamine uptake (r = 0.02) or differ between patients and controls. Uptake of [3H]dopamine by PRP from 52 volunteers (26 M, 26 F; age, 18-75 yr), expressed as the area under the dopamine uptake curve up to 60 min in arbitrary units, ranged from 72-285 for males and 59-455 for females. Comparing [3H]dopamine uptake by PRP from 15 psychotic patients to these sex-specific reference ranges 9 of 13 PRP from schizophrenic patients had [3H]dopamine uptake outside the normative values whereas the two non-schizophrenic patients did not differ from normal. Dopamine uptake by PRP may be useful in the study of diseases with altered dopaminergic activity in the CNS. | lld:pubmed |
| pubmed-article:2317927 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2317927 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317927 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2317927 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2317927 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2317927 | pubmed:issn | 0009-8981 | lld:pubmed |
| pubmed-article:2317927 | pubmed:author | pubmed-author:DeanBB | lld:pubmed |
| pubmed-article:2317927 | pubmed:author | pubmed-author:CopolovD LDL | lld:pubmed |
| pubmed-article:2317927 | pubmed:author | pubmed-author:KulkarniJJ | lld:pubmed |
| pubmed-article:2317927 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2317927 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:2317927 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:2317927 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2317927 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2317927 | pubmed:pagination | 37-46 | lld:pubmed |
| pubmed-article:2317927 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:meshHeading | pubmed-meshheading:2317927-... | lld:pubmed |
| pubmed-article:2317927 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2317927 | pubmed:articleTitle | Validation of a method to measure the uptake of [3H]dopamine by human platelets. | lld:pubmed |
| pubmed-article:2317927 | pubmed:affiliation | Mental Health Research Institute of Victoria, Parkville, Australia. | lld:pubmed |
| pubmed-article:2317927 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2317927 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
