| pubmed-article:2316668 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C0039400 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C1622418 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C0000098 | lld:lifeskim |
| pubmed-article:2316668 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:2316668 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:2316668 | pubmed:dateCreated | 1990-4-23 | lld:pubmed |
| pubmed-article:2316668 | pubmed:abstractText | Rabbit renal brush-border membrane vesicles (BBMV) were used to study the transport of the cationic neurotoxin, 1-methyl-4-phenylpyridinium (MPP+). An outwardly directed H(+)-gradient stimulated MPP+ uptake and led to the development of an active accumulation of MPP+ within the vesicles. H(+)-gradient driven MPP+ transport was saturable, with a maximal transport rate of 3 nmol.mg-1.min-1 and an apparent Michaelis constant (Kt) of 8 microM. MPP+ and tetraethylammonium (TEA) behaved as competitive inhibitors of one another's transport in renal BBMV, suggesting the presence of a common transport pathway for these organic cations. At an ambient pH of 7.5, preloading BBMV with MPP+ failed to stimulate TEA uptake, although trans TEA did stimulate MPP+ uptake. Increasing ambient pH to 8.5 (i.e., reducing competition between H+ and these organic cations for a common transport pathway) led to a clear reciprocal trans stimulation of TEA and MPP+ fluxes. With an equilibrium-shift protocol, a trans concentration of MPP+ energized uphill transport of TEA. We conclude that MPP+ and TEA share a common organic cation-H+ exchange pathway in the renal brush border, although turnover of an MPP(+)-loaded exchanger is slow compared with that for a TEA or H(+)-loaded exchanger. | lld:pubmed |
| pubmed-article:2316668 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2316668 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316668 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2316668 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2316668 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2316668 | pubmed:author | pubmed-author:WrightS HSH | lld:pubmed |
| pubmed-article:2316668 | pubmed:author | pubmed-author:LazarukK DKD | lld:pubmed |
| pubmed-article:2316668 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2316668 | pubmed:volume | 258 | lld:pubmed |
| pubmed-article:2316668 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2316668 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2316668 | pubmed:pagination | F597-605 | lld:pubmed |
| pubmed-article:2316668 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
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| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
| pubmed-article:2316668 | pubmed:meshHeading | pubmed-meshheading:2316668-... | lld:pubmed |
| pubmed-article:2316668 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2316668 | pubmed:articleTitle | MPP+ is transported by the TEA(+)-H+ exchanger of renal brush-border membrane vesicles. | lld:pubmed |
| pubmed-article:2316668 | pubmed:affiliation | Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85724. | lld:pubmed |
| pubmed-article:2316668 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2316668 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
