| pubmed-article:2316016 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2316016 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:2316016 | lifeskim:mentions | umls-concept:C0023895 | lld:lifeskim |
| pubmed-article:2316016 | lifeskim:mentions | umls-concept:C1709854 | lld:lifeskim |
| pubmed-article:2316016 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2316016 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:2316016 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2316016 | pubmed:dateCreated | 1990-4-18 | lld:pubmed |
| pubmed-article:2316016 | pubmed:abstractText | To establish the impact of cyclosporine on the development of chronic hepatitis in hepatitis B surface antigen (HBsAg)-positive renal allograft recipients, the incidence and outcome of chronic hepatitis in 20 cyclosporine-treated patients (CsA group) were compared with 13 azathioprine-treated patients (AZA group). All 33 patients had a functioning graft for 2 years or longer. Twenty-nine of the 33 patients were HBsAg-positive prior to the initiation of hemodialysis. The difference in the incidence of chronic hepatitis between these 2 groups was not statistically significant (78.6% in the AZA group vs. 52.4% in the CsA group, P = 0.12). In the CsA group, 3 patients (15%) developed liver cirrhosis, and there was a 5% mortality. The AZA group had a 7.7% mortality, and 4 patients (30.8%) developed liver cirrhosis. Serial serum samples obtained from these 33 HBsAg-positive renal allograft recipients were analyzed for antibody to hepatitis D virus (anti-HD). Anti-HD was found in 3 patients. Two of them developed anti-HD seroconversion after renal transplantation during a mean follow-up of 4 years. All 3 patients developed chronic hepatitis and 2 of them have subsequently developed liver cirrhosis. There was a mortality of 6.1% in 33 HBsAg-positive patients compared with a 5.3% mortality in 57 HBsAg-negative renal allograft recipients. The difference was not statistically significant. We conclude from this study that (1) CsA-treated HBsAg-positive renal allograft recipients have a tendency to develop chronic hepatitis like AZA-treated patients; (2) HBsAg-positive patients have an increased risk of HDV superinfection after renal transplantation, and this may result in rapid progression to liver cirrhosis; (3) HBsAg-positive patients who acquire HBsAg prior to renal transplantation have a low overall mortality, including death due to liver disease, for a mean follow-up of 4 years. | lld:pubmed |
| pubmed-article:2316016 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2316016 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2316016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2316016 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2316016 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2316016 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:2316016 | pubmed:author | pubmed-author:HuangC CCC | lld:pubmed |
| pubmed-article:2316016 | pubmed:author | pubmed-author:LaiM KMK | lld:pubmed |
| pubmed-article:2316016 | pubmed:author | pubmed-author:FongM TMT | lld:pubmed |
| pubmed-article:2316016 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2316016 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:2316016 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2316016 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2316016 | pubmed:pagination | 540-4 | lld:pubmed |
| pubmed-article:2316016 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2316016 | pubmed:meshHeading | pubmed-meshheading:2316016-... | lld:pubmed |
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| pubmed-article:2316016 | pubmed:meshHeading | pubmed-meshheading:2316016-... | lld:pubmed |
| pubmed-article:2316016 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2316016 | pubmed:articleTitle | Hepatitis B liver disease in cyclosporine-treated renal allograft recipients. | lld:pubmed |
| pubmed-article:2316016 | pubmed:affiliation | Department of Medicine and Surgery, Chang Gung Memorial Hospital, Chang Gung Medical School, Taipei, Taiwan, Republic of China. | lld:pubmed |
| pubmed-article:2316016 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2316016 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
