| pubmed-article:2313935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0205042 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0201925 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:2313935 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2313935 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2313935 | pubmed:dateCreated | 1990-4-26 | lld:pubmed |
| pubmed-article:2313935 | pubmed:abstractText | Effects of histamine on the tone and intracellular calcium level (Ca2+i) in porcine coronary arteries were simultaneously investigated by use of the fura-2 microscopic fluorometric method. Histamine (10(-6)-10(-4) M) induced concentration-dependent increases in tone and Ca2+i, but these responses were not sustained. Histamine induced a larger contraction than did KCl with a similar increase in Ca2+i. Depletion of the caffeine-sensitive Ca2+ store with ryanodine (3 x 10(-5) M) and repetitive applications of caffeine (2.5 x 10(-2) M) scarcely affected contractile and Ca2+i responses to histamine. In Ca2(+)-free medium or in the presence of verapamil (10(-6) M), histamine produced a briefer increase in Ca2+i and a smaller contraction than in normal medium. When histamine or caffeine was repetitively applied in Ca2(+)-free medium, the first application produced an increase in Ca2+i but the second application produced no increase. Although caffeine increased Ca2+i after repetitive histamine applications, histamine failed to increase Ca2+i after repetitive caffeine applications in Ca2(+)-free medium. These results indicate that vascular contraction induced by histamine may involve the following mechanisms: an increase in Ca2+ influx through Ca2+ channels, release of Ca2+ from the intracellular Ca2+ store which has an interaction with the caffeine-sensitive Ca2+ store, and sensitization of contractile proteins to Ca2+. | lld:pubmed |
| pubmed-article:2313935 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2313935 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2313935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2313935 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2313935 | pubmed:issn | 0021-5198 | lld:pubmed |
| pubmed-article:2313935 | pubmed:author | pubmed-author:MoriTT | lld:pubmed |
| pubmed-article:2313935 | pubmed:author | pubmed-author:TairaNN | lld:pubmed |
| pubmed-article:2313935 | pubmed:author | pubmed-author:YanagisawaTT | lld:pubmed |
| pubmed-article:2313935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2313935 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:2313935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2313935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2313935 | pubmed:pagination | 263-71 | lld:pubmed |
| pubmed-article:2313935 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2313935 | pubmed:meshHeading | pubmed-meshheading:2313935-... | lld:pubmed |
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| pubmed-article:2313935 | pubmed:meshHeading | pubmed-meshheading:2313935-... | lld:pubmed |
| pubmed-article:2313935 | pubmed:meshHeading | pubmed-meshheading:2313935-... | lld:pubmed |
| pubmed-article:2313935 | pubmed:meshHeading | pubmed-meshheading:2313935-... | lld:pubmed |
| pubmed-article:2313935 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2313935 | pubmed:articleTitle | Histamine increases vascular tone and intracellular calcium level using both intracellular and extracellular calcium in porcine coronary arteries. | lld:pubmed |
| pubmed-article:2313935 | pubmed:affiliation | Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan. | lld:pubmed |
| pubmed-article:2313935 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2313935 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2313935 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2313935 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2313935 | lld:pubmed |
