| pubmed-article:2308007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0031268 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0185115 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C2350393 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C1527121 | lld:lifeskim |
| pubmed-article:2308007 | lifeskim:mentions | umls-concept:C1522485 | lld:lifeskim |
| pubmed-article:2308007 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2308007 | pubmed:dateCreated | 1990-4-9 | lld:pubmed |
| pubmed-article:2308007 | pubmed:abstractText | Copper(II) pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-PTSM), copper(II) pyruvaldehyde bis(N4-dimethylthiosemicarbazone) (Cu-PTSM2), and copper(II) ethylglyoxal bis(N4-methylthiosemicarbazone) (Cu-ETSM), have been proposed as PET tracers for cerebral blood flow (CBF) when labeled with generator-produced 62Cu (t1/2 = 9.7 min). To evaluate the potential of Cu-PTSM for CBF PET studies, baboon single-pass cerebral extraction measurements and PET imaging were carried out with the use of 67Cu (t1/2 = 2.6 days) and 64Cu (t1/2 = 12.7 hr), respectively. All three chelates were extracted into the brain with high efficiency. There was some clearance of all chelates in the 10-50-sec time frame and Cu-PTSM2 continued to clear. Cu-PTSM and Cu-ETSM have high residual brain activity. PET imaging of baboon brain was carried out with the use of [64Cu]-Cu-PTSM. For comparison with the 64Cu brain image, a CBF (15O-labeled water) image (40 sec) was first obtained. Qualitatively, the H2(15)O and [64Cu]-Cu-PTSM images were very similar; for example, a comparison of gray to white matter uptake resulted in ratios of 2.42 for H2(15)O and 2.67 for Cu-PTSM. No redistribution of 64Cu was observed in 2 hr of imaging, as was predicted from the single-pass study results. Quantitative determination of blood flow using Cu-PTSM showed good agreement with blood flow determined with H2(15)O. This data suggests that [62Cu]-Cu-PTSM may be a useful generator-produced radiopharmaceutical for blood flow studies with PET. | lld:pubmed |
| pubmed-article:2308007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2308007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2308007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2308007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2308007 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2308007 | pubmed:issn | 0161-5505 | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:WelchM JMJ | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:RaichleM EME | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:MathiasC JCJ | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:GreenM AMA | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:ZinnK RKR | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:JohnE KEK | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:MintunM AMA | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:McGuireA HAH | lld:pubmed |
| pubmed-article:2308007 | pubmed:author | pubmed-author:LichL LLL | lld:pubmed |
| pubmed-article:2308007 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2308007 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2308007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2308007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2308007 | pubmed:pagination | 351-9 | lld:pubmed |
| pubmed-article:2308007 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:meshHeading | pubmed-meshheading:2308007-... | lld:pubmed |
| pubmed-article:2308007 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2308007 | pubmed:articleTitle | Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM. | lld:pubmed |
| pubmed-article:2308007 | pubmed:affiliation | Department of Radiology, Washington University School of Medicine, St. Louis, Missouri. | lld:pubmed |
| pubmed-article:2308007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2308007 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2308007 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2308007 | lld:pubmed |
