| pubmed-article:2305611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0024591 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:2305611 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:2305611 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2305611 | pubmed:dateCreated | 1990-3-29 | lld:pubmed |
| pubmed-article:2305611 | pubmed:abstractText | Calcium accumulation by the sarcoplasmic reticulum in whole muscle homogenate preparations of malignant hyperthermia-susceptible (MH+) and non-susceptible (MH-) humans and pigs was investigated using a calcium electrode at 35 degrees C. Sarcoplasmic reticulum of MH+ humans and pigs showed normal Ca2+ accumulation, with no difference being observed in the rate and the time taken to achieve maximal accumulation. However, the capacity for Ca2+ accumulation by the sarcoplasmic reticulum in MH+ humans and pigs is considerably less stable than normal after prolonged ageing of the whole muscle homogenate preparations in ice. In MH+ patients, the capacity for Ca2+ accumulation by the sarcoplasmic reticulum showed a decline of 62% at 22 h ageing and 70% at 48 h ageing, as compared with a reduction of only 23% in MH- patients. In MH+ pigs, the sarcoplasmic reticulum showed a 96% deterioration in the capacity for Ca2+ accumulation as compared with a loss of only 40% in MH- pigs at 7 h ageing in ice. In both humans and pigs, the decline in Ca2+ accumulation was prevented by incubating the whole muscle homogenate preparations for 2 h at 35 degrees C prior to ageing the preparations. The diminished Ca2+ accumulating capacity of the sarcoplasmic reticulum in whole muscle homogenate preparations of MH-susceptible individuals in our experimental protocol provides a potential diagnostic test for malignant hyperthermia susceptibility. | lld:pubmed |
| pubmed-article:2305611 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2305611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2305611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2305611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2305611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2305611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2305611 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2305611 | pubmed:issn | 0001-5172 | lld:pubmed |
| pubmed-article:2305611 | pubmed:author | pubmed-author:RosenbergHH | lld:pubmed |
| pubmed-article:2305611 | pubmed:author | pubmed-author:FletcherJ EJE | lld:pubmed |
| pubmed-article:2305611 | pubmed:author | pubmed-author:CheahK SKS | lld:pubmed |
| pubmed-article:2305611 | pubmed:author | pubmed-author:CheahA MAM | lld:pubmed |
| pubmed-article:2305611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2305611 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:2305611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2305611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2305611 | pubmed:pagination | 114-9 | lld:pubmed |
| pubmed-article:2305611 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:meshHeading | pubmed-meshheading:2305611-... | lld:pubmed |
| pubmed-article:2305611 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2305611 | pubmed:articleTitle | Calcium accumulation by sarcoplasmic reticulum in whole muscle homogenate preparations of malignant hyperthermia diagnostic patients and pigs. | lld:pubmed |
| pubmed-article:2305611 | pubmed:affiliation | Department of Anesthesiology, Hahnemann University, Philadelphia. | lld:pubmed |
| pubmed-article:2305611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2305611 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2305611 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2305611 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
