| pubmed-article:2303453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0017963 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1517880 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1516144 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:2303453 | lifeskim:mentions | umls-concept:C1321758 | lld:lifeskim |
| pubmed-article:2303453 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2303453 | pubmed:dateCreated | 1990-3-23 | lld:pubmed |
| pubmed-article:2303453 | pubmed:abstractText | The extreme carboxyl-terminal amino acid sequence of the gamma chain of fibrinogen is involved in the binding of this adhesive protein to the platelet integrin glycoprotein (GP) IIb-IIIa, and synthetic peptides corresponding to this region inhibit fibrinogen as well as fibronectin and von Willebrand factor binding to platelets. A chemical cross-linking approach was used to characterize the interaction of a 16-amino acid fibrinogen gamma chain peptide with platelets and to localize the site of its binding to GPIIb-IIIa. This peptide became specifically cross-linked to GPIIb, and platelet stimulation selectively enhanced its cross-linking to this alpha subunit. The cross-linking reaction was specifically inhibited by fibrinogen and an Arg-Gly-Asp peptide but not by an unrelated protein or a substituted peptide. Utilizing a combination of immunochemical mapping, enzymatic and chemical digestions, and amino acid sequencing, the cross-linking site of the gamma chain peptide in GPIIb was localized to a stretch of 21 amino acids. The identified region, GPIIb 294-314, contains the second putative calcium binding domain within GPIIb. The primary structure of this region is highly conserved among alpha subunits of other integrin adhesion receptors. These results identify a discrete region of GPIIb that resides in close proximity to a ligand binding site within GPIIb-IIIa. The homologous region may be involved in the functions of other integrin receptors. | lld:pubmed |
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| pubmed-article:2303453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2303453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2303453 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2303453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2303453 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2303453 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2303453 | pubmed:author | pubmed-author:PlowE FEF | lld:pubmed |
| pubmed-article:2303453 | pubmed:author | pubmed-author:GinsbergM HMH | lld:pubmed |
| pubmed-article:2303453 | pubmed:author | pubmed-author:BurkeT ATA | lld:pubmed |
| pubmed-article:2303453 | pubmed:author | pubmed-author:D'SouzaS ESE | lld:pubmed |
| pubmed-article:2303453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2303453 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:2303453 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:2303453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2303453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2303453 | pubmed:pagination | 3440-6 | lld:pubmed |
| pubmed-article:2303453 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2303453 | pubmed:meshHeading | pubmed-meshheading:2303453-... | lld:pubmed |
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| pubmed-article:2303453 | pubmed:meshHeading | pubmed-meshheading:2303453-... | lld:pubmed |
| pubmed-article:2303453 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2303453 | pubmed:articleTitle | The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. | lld:pubmed |
| pubmed-article:2303453 | pubmed:affiliation | Committee on Vascular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037. | lld:pubmed |
| pubmed-article:2303453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2303453 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2303453 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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