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pubmed-article:2302006pubmed:abstractTextUsing modern electrode technology (Beckman ASTRA analyzer), we evaluated the reference range for the anion gap (calculated as sodium minus chloride minus bicarbonate concentrations) in serum to determine whether the 8 to 16 mmol/L reference range in common use is still valid. After measurement of electrolytes in (1) serum from 29 healthy volunteers, (2) aqueous standards verified against National Bureau of Standards reference material, and (3) serum from 120 blood donors, we drew the following conclusions. (1) The reference range for the anion gap has shifted downward (to 3 to 11 mmol/L in one of our laboratories), primarily because of an upward shift in chloride values. (2) Using the ASTRA analyzer, a majority of normal individuals can be expected to have serum anion gaps of 6 mmol/L or less unless chloride calibration is deliberately altered. (3) If the anion gap is to remain an effective tool in diagnosing acid-base disorders, clinicians need to be aware that the traditional reference range may not be appropriate with new instrumentation.lld:pubmed
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pubmed-article:2302006pubmed:authorpubmed-author:PearsonJ RJRlld:pubmed
pubmed-article:2302006pubmed:authorpubmed-author:GabowP APAlld:pubmed
pubmed-article:2302006pubmed:authorpubmed-author:SchultzA LALlld:pubmed
pubmed-article:2302006pubmed:authorpubmed-author:WinterS DSDlld:pubmed
pubmed-article:2302006pubmed:authorpubmed-author:LepoffR BRBlld:pubmed
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pubmed-article:2302006pubmed:pagination311-3lld:pubmed
pubmed-article:2302006pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:2302006pubmed:year1990lld:pubmed
pubmed-article:2302006pubmed:articleTitleThe fall of the serum anion gap.lld:pubmed
pubmed-article:2302006pubmed:affiliationClinical Laboratory, Denver General Hospital, Colo 80204-4507.lld:pubmed
pubmed-article:2302006pubmed:publicationTypeJournal Articlelld:pubmed
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