| pubmed-article:2298915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0241888 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0042875 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0969677 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:2298915 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:2298915 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2298915 | pubmed:dateCreated | 1990-3-15 | lld:pubmed |
| pubmed-article:2298915 | pubmed:abstractText | Plasma and lipoprotein alpha-tocopherol concentrations of four patients with familial isolated vitamin E deficiency and six control subjects were observed for 4 d after an oral dose (approximately 15 mg) of RRR-alpha-tocopheryl acetate labeled with six deuterium atoms (d6-tocopherol). Chylomicron d6-tocopherol concentrations were similar in the two groups. d6-Tocopherol concentrations of plasma, very low (VLDL), low (LDL), and high (HDL) density lipoproteins were similar in the two groups only during the first 12 h; then these were significantly lower, and the rate of disappearance faster, in the patients. The times (tmax) of the maximum chylomicron d6-tocopherol concentrations were similar for the two groups, but tmax values in the controls increased in the order: chylomicrons less than VLDL less than or equal to LDL approximately HDL, while the corresponding values in the patients were similar to the chylomicron tmax. Thus, plasma d6-tocopherol in controls increased during chylomicron and VLDL catabolism, whereas in patients it increased only during chylomicron catabolism, thereby resulting in a premature and faster decline in the plasma tocopherol concentration due to a lack of d6-tocopherol secretion from the liver. We suggest that these patients are lacking or have a defective liver "tocopherol binding protein" that incorporates alpha-tocopherol into nascent VLDL. | lld:pubmed |
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| pubmed-article:2298915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2298915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2298915 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2298915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2298915 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2298915 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:SokolR JRJ | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:KaydenH JHJ | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:BurtonG WGW | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:TraberM GMG | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:IngoldK UKU | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:PapasA MAM | lld:pubmed |
| pubmed-article:2298915 | pubmed:author | pubmed-author:HuffakerJ EJE | lld:pubmed |
| pubmed-article:2298915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2298915 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2298915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2298915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2298915 | pubmed:pagination | 397-407 | lld:pubmed |
| pubmed-article:2298915 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2298915 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2298915 | pubmed:articleTitle | Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. | lld:pubmed |
| pubmed-article:2298915 | pubmed:affiliation | Department of Medicine, New York University School of Medicine, New York 10016. | lld:pubmed |
| pubmed-article:2298915 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2298915 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2298915 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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