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pubmed-article:2297316pubmed:abstractTextAcanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition.lld:pubmed
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pubmed-article:2297316pubmed:pagination107-12lld:pubmed
pubmed-article:2297316pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2297316pubmed:year1990lld:pubmed
pubmed-article:2297316pubmed:articleTitlePathogenicity of Acanthamoeba and a Corynebacterium in the rat cornea.lld:pubmed
pubmed-article:2297316pubmed:affiliationDepartment of Ophthalmology, Flinders Medical Centre, Bedford Park, South Australia.lld:pubmed
pubmed-article:2297316pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2297316pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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