| pubmed-article:2296584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2296584 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2296584 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2296584 | pubmed:dateCreated | 1990-2-9 | lld:pubmed |
| pubmed-article:2296584 | pubmed:abstractText | Light-flash photolysis of caged inositol 1,4,5-trisphosphate (InsP3) was used to generate reproducible transients of free InsP3 in Xenopus oocytes, and the resulting liberation of Ca2+ from intracellular stores was monitored by recording Ca2+-activated membrane currents and by use of the fluorescent Ca2+ indicator fluo-3. InsP3-mediated Ca2+ release was inhibited by elevating the intracellular free Ca2+ level, either by microinjecting Ca2+ into the cell or by applying conditioning light flashes to liberate Ca2+. This inhibition followed a slow time course, being maximal after about 2 s and subsequently declining over several seconds. Negative feedback of Ca2+ ions on InsP3-mediated Ca2+ liberation may explain the oscillatory release of Ca2+ seen during activation of inositol phospholipid signaling in the oocyte, and the time course of the inhibition is consistent with the period of the oscillations. | lld:pubmed |
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| pubmed-article:2296584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2296584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2296584 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2296584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2296584 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2296584 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2296584 | pubmed:author | pubmed-author:ParkerII | lld:pubmed |
| pubmed-article:2296584 | pubmed:author | pubmed-author:IvorraII | lld:pubmed |
| pubmed-article:2296584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2296584 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:2296584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2296584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2296584 | pubmed:pagination | 260-4 | lld:pubmed |
| pubmed-article:2296584 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2296584 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2296584 | pubmed:articleTitle | Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+. | lld:pubmed |
| pubmed-article:2296584 | pubmed:affiliation | Department of Psychobiology, University of California, Irvine 92715. | lld:pubmed |
| pubmed-article:2296584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2296584 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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