| pubmed-article:2280177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C0020443 | lld:lifeskim |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C0003593 | lld:lifeskim |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:2280177 | lifeskim:mentions | umls-concept:C1704417 | lld:lifeskim |
| pubmed-article:2280177 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2280177 | pubmed:dateCreated | 1991-3-13 | lld:pubmed |
| pubmed-article:2280177 | pubmed:abstractText | Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to the low density lipoprotein receptor. Low density lipoproteins accumulate in the plasma because their efficient receptor-mediated catabolism is disrupted. This mutation has been identified in the United States, Canada, and Europe and is estimated to occur at a frequency of approximately 1/500 in these populations. Thus, it appears that this newly described disorder may be a significant genetic cause of hypercholesterolemia in Western societies. | lld:pubmed |
| pubmed-article:2280177 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2280177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2280177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2280177 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2280177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2280177 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2280177 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:McCarthyB JBJ | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:KraussR MRM | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:MahleyR WRW | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:BersotT PTP | lld:pubmed |
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| pubmed-article:2280177 | pubmed:author | pubmed-author:FriedlWW | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:GrundyS MSM | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:WeisgraberK... | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:DavignonJJ | lld:pubmed |
| pubmed-article:2280177 | pubmed:author | pubmed-author:VegaG LGL | lld:pubmed |
| pubmed-article:2280177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2280177 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2280177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2280177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2280177 | pubmed:pagination | 1337-49 | lld:pubmed |
| pubmed-article:2280177 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2280177 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2280177 | pubmed:articleTitle | Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. | lld:pubmed |
| pubmed-article:2280177 | pubmed:affiliation | Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140-0608. | lld:pubmed |
| pubmed-article:2280177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2280177 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2280177 | pubmed:publicationType | Review | lld:pubmed |
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