| pubmed-article:227789 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0021338 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0008051 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0086574 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:227789 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:227789 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:227789 | pubmed:dateCreated | 1980-1-28 | lld:pubmed |
| pubmed-article:227789 | pubmed:abstractText | The in vitro susceptibility of chicken lymphocytes to a wild strains of infectious bursal disease virus was investigated by using immunofluorescence and virus assays as infection criteria. A variety of Marek's disease lymphoblastoid cell lines, all of thymus (T-cell) origin, were refractory to virus exposure. However, a bursa (B-cell)-derived lymphoblastoid cell line from an avian leukosis virus-induced tumor was highly susceptible. Viral antigen appeared in the cytoplasm of 20 to 30% of the cells, and large amounts of cell-free virus were released, with maximum yields occurring by 3 days postinfeciton. The virus also replicated in a small percentage of normal lymphocytes prepared from lymphoid tissues and peripheral blood of chickens. Pretreatment of the lymphocytes, with heat-inactivated anti-B-cell serum or with antiserum against fowl immunoglobulin M before inoculating them with the virus blocked the virus infection; no blocking occurred with anti-T-cell serum or with specific antiserum against fowl immunoglobulin G or immunoglobulin A. This suggests that surface immunoglobulin M-bearing B-lymphocytes were the target cells for infection. | lld:pubmed |
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| pubmed-article:227789 | pubmed:language | eng | lld:pubmed |
| pubmed-article:227789 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:227789 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:227789 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:227789 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:227789 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:227789 | pubmed:author | pubmed-author:HiraiKK | lld:pubmed |
| pubmed-article:227789 | pubmed:author | pubmed-author:CalnekB WBW | lld:pubmed |
| pubmed-article:227789 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:227789 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:227789 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:227789 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:227789 | pubmed:pagination | 964-70 | lld:pubmed |
| pubmed-article:227789 | pubmed:dateRevised | 2010-9-2 | lld:pubmed |
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| pubmed-article:227789 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:227789 | pubmed:articleTitle | In vitro replication of infectious bursal disease virus in established lymphoid cell lines and chicken B lymphocytes. | lld:pubmed |
| pubmed-article:227789 | pubmed:publicationType | Journal Article | lld:pubmed |
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