| pubmed-article:2274705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C0596890 | lld:lifeskim |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C0076729 | lld:lifeskim |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C1710265 | lld:lifeskim |
| pubmed-article:2274705 | lifeskim:mentions | umls-concept:C1259921 | lld:lifeskim |
| pubmed-article:2274705 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2274705 | pubmed:dateCreated | 1991-2-28 | lld:pubmed |
| pubmed-article:2274705 | pubmed:abstractText | The kinetic of release of the tissular polypeptide antigen (TPA) by MCF-7 cells synchronised by sequential treatment with hydroxytamoxifen (OH-TAM) and 17 beta-estradiol has been studied. The present findings confirm the proliferative effect of estradiol on MCF-7 cells, with a shortening of the doubling time (TD) (22.2 h versus 24.8 h) and an increase in the growing fraction (Fc) (94% versus 81%) when compared with the same parameters measured in cells rescued from OH-TAM but not treated with estradiol. In addition, the action of estradiol was followed by a simultaneous increase in the amount of TPA in the culture medium related with the phases G2/M and G1 of the mitotic cycle. This phenomenon seems to be the reason for the steplike shape of the TPA released curves. The experimental results suggest that in MCF-7 cells the sequential combination of antiestrogenic agents and estrogens leads to a cellular synchronization. Furthermore this synchronization is maintained for at least 3 cycles of cell division. | lld:pubmed |
| pubmed-article:2274705 | pubmed:language | spa | lld:pubmed |
| pubmed-article:2274705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2274705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2274705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2274705 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2274705 | pubmed:issn | 0034-9402 | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:OleaNN | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:FernándezJ... | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:Ruiz de... | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:PedrazaVV | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:López-Gonzále... | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:del MoralRR | lld:pubmed |
| pubmed-article:2274705 | pubmed:author | pubmed-author:GorgojoLL | lld:pubmed |
| pubmed-article:2274705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2274705 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:2274705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2274705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2274705 | pubmed:pagination | 205-10 | lld:pubmed |
| pubmed-article:2274705 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:meshHeading | pubmed-meshheading:2274705-... | lld:pubmed |
| pubmed-article:2274705 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2274705 | pubmed:articleTitle | [Tissue polypeptide antigen liberation and proliferation of MCF-7 cells after synchronization with hydroxytamoxifen and rescue with estradiol]. | lld:pubmed |
| pubmed-article:2274705 | pubmed:affiliation | Departamento de Radiología, Hospital Clínico Universitario, Facultad de Medicina, Universidad de Granada, España. | lld:pubmed |
| pubmed-article:2274705 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2274705 | pubmed:publicationType | English Abstract | lld:pubmed |
