| pubmed-article:227308 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C0039067 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:227308 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:227308 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:227308 | pubmed:dateCreated | 1979-12-29 | lld:pubmed |
| pubmed-article:227308 | pubmed:abstractText | The mechanisms of dopamine (DA) release central nerve endings have been investigated utilizing superfused rat striatal synaptosomes. Nomifensine was selected as a tool to discriminate between release mediated by the DA carrier and release occurring independently of the carrier. The following conclusions can be drawn from the results obtained: 1) Alterations of the sodium gradient across the synaptosomal membrane, induced by omission of extracellular Na+ or by ouabain, enhanced the release of 3H-DA from prelabeled synaptosomes. The release was blocked by nomifensine and therefore it was carrier-mediated. 2) The release of DA elicited by amphetamine and related phenylethylamines was nomifensine-sensitive, suggesting that the released DA existed from synaptosomes through the membrane carrier. 3) Depolarization of synaptosomes by high K+ triggered the release of both "newly taken up" and "newly synthesized" DA. 4) The calcium-dependent release of DA (induced by high K+, veratridine of by the ionophore A23187) was not affected by the carrier blocker nomifensine and may occur by an exocytic-like process. 5) The effects of apomorphine and neuroleptics on the stimulus-evoked release of DA do not support the existence of a presynaptic receptor-mediated inhibitory control of DA release identical to that described for noradrenaline. | lld:pubmed |
| pubmed-article:227308 | pubmed:language | eng | lld:pubmed |
| pubmed-article:227308 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:227308 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:227308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:227308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:227308 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:227308 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:227308 | pubmed:issn | 0021-2571 | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:RaiteriMM | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:LeviGG | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:CerritoFF | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:CervoniA MAM | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:RiberaM TMT | lld:pubmed |
| pubmed-article:227308 | pubmed:author | pubmed-author:Del CarmineRR | lld:pubmed |
| pubmed-article:227308 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:227308 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:227308 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:227308 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:227308 | pubmed:pagination | 97-110 | lld:pubmed |
| pubmed-article:227308 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-A... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-R... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-C... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-N... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-N... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-D... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-F... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-S... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-R... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-S... | lld:pubmed |
| pubmed-article:227308 | pubmed:meshHeading | pubmed-meshheading:227308-N... | lld:pubmed |
| pubmed-article:227308 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:227308 | pubmed:articleTitle | Release of dopamine from striatal synaptosomes. | lld:pubmed |
| pubmed-article:227308 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:227308 | lld:pubmed |
