| pubmed-article:2265457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0194083 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C0681814 | lld:lifeskim |
| pubmed-article:2265457 | lifeskim:mentions | umls-concept:C2347957 | lld:lifeskim |
| pubmed-article:2265457 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2265457 | pubmed:dateCreated | 1991-2-12 | lld:pubmed |
| pubmed-article:2265457 | pubmed:abstractText | Groups of mature Large White female pigs, approximately 10 months of age, received single intravenous infusions of 1.5, 2 or 2.5 mg/kg body weight (equivalent to approximately 90, approximately 120 and approximately 150 mg/m2) cisplatin. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured before and at 4 weeks after cisplatin infusion by renography using [99 mTc]-DTPA (diethylenetriamminepentaacetic acid and iodohippurate sodium I 131, respectively. The left kidney of each cisplatin-treated animal plus that of four age-matched control pigs was then removed surgically, and GFR and ERPF were measured in the remaining kidney at 4 weekly intervals for up to 24 weeks after unilateral nephrectomy (UN). The pigs treated with cisplatin exhibited no consistent change in either GFR or ERPF at 4 weeks after treatment. A histological evaluation of kidneys from animals treated with greater than or equal to 2 mg/kg cisplatin that had been removed at UN revealed both tubular and glomerular lesions. The latter consisted of cell proliferation on the parietal surface of the urinary space; damage to the S1 portion of the proximal convolution was also noted. Following UN there was a pronounced dose-dependent reduction in the functional status of the remaining kidney such that the increase in GFR and ERPF in pigs initially receiving 2.5 mg/kg cisplatin was less than 50% of that seen in age-matched UN controls. Moreover, the glomerular lesions observed at 4 weeks after cisplatin infusion had apparently progressed to glomerular hyalinisation by 24 weeks after UN. Thus, prior treatment with cisplatin may cause a permanent reduction in renal functional reserve that may be clinically "silent" until exposure to an additional nephrotoxic insult. | lld:pubmed |
| pubmed-article:2265457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2265457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2265457 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2265457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2265457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2265457 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:2265457 | pubmed:author | pubmed-author:MichalowskiAA | lld:pubmed |
| pubmed-article:2265457 | pubmed:author | pubmed-author:RobbinsM EME | lld:pubmed |
| pubmed-article:2265457 | pubmed:author | pubmed-author:HopewellJ WJW | lld:pubmed |
| pubmed-article:2265457 | pubmed:author | pubmed-author:WhitehouseEE | lld:pubmed |
| pubmed-article:2265457 | pubmed:author | pubmed-author:CamplingDD | lld:pubmed |
| pubmed-article:2265457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2265457 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:2265457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2265457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2265457 | pubmed:pagination | 211-8 | lld:pubmed |
| pubmed-article:2265457 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:meshHeading | pubmed-meshheading:2265457-... | lld:pubmed |
| pubmed-article:2265457 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2265457 | pubmed:articleTitle | Cisplatin-induced reductions in renal functional reserve uncovered by unilateral nephrectomy: an experimental study in the pig. | lld:pubmed |
| pubmed-article:2265457 | pubmed:affiliation | Normal Tissue Radiobiology Research Group, Research Institute (University of Oxford), Churchill Hospital, UK. | lld:pubmed |
| pubmed-article:2265457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2265457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
