| pubmed-article:2262494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C0740038 | lld:lifeskim |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C1964018 | lld:lifeskim |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C0175566 | lld:lifeskim |
| pubmed-article:2262494 | lifeskim:mentions | umls-concept:C2349101 | lld:lifeskim |
| pubmed-article:2262494 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2262494 | pubmed:dateCreated | 1991-2-4 | lld:pubmed |
| pubmed-article:2262494 | pubmed:abstractText | Several laboratories have found canine platelet aggregometry predictive of thrombotic potential in vascular grafts. Adenosine diphosphate (ADP) is a frequently used agonist, often at unspecified or differing concentrations. This study was designed to evaluate the predictive value of ADP-induced platelet aggregometry and the validity of the methodology. Platelet aggregometry in response to 2 x 10(-5) M ADP was assayed in 70 dogs. Twenty-six percent were aggregators, 51% were non-aggregators, and 20% were indeterminant. All dogs were then treated with aspirin and dipyridamole. Vascular prostheses were implanted bilaterally (aorto-iliac) and anti-platelet therapy continued for two weeks. Dose-response to ADP was studied at three concentrations in 20 dogs. At 2 x 10(-5) 1/20 aggregated, at 4 x 10(-5) 3/19 aggregated and at 2 x 10(-4) 15/20 aggregated. Time between samples and study was evaluated in 11 dogs, with 2/11 changing from non-aggregator to aggregator at two or three hours. Daily reproducibility was studied in 70 dogs, 14 of which changed aggregation status between days. Patency was 58/68 (85%) for non-aggregators, 23/34 (68%) for aggregators (p = 0.038). Platelet aggregometry has significant predictive value for graft patency but methodology must be specified and standardized. | lld:pubmed |
| pubmed-article:2262494 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2262494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262494 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2262494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2262494 | pubmed:issn | 0021-9509 | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:HendersonS... | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:EllingerJJ | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:GreislerH PHP | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:KlosakJ JJJ | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:TattersallC... | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:CabusaoE AEA | lld:pubmed |
| pubmed-article:2262494 | pubmed:author | pubmed-author:McGurrinJ FJF | lld:pubmed |
| pubmed-article:2262494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2262494 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2262494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2262494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2262494 | pubmed:pagination | 712-8 | lld:pubmed |
| pubmed-article:2262494 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:2262494 | pubmed:meshHeading | pubmed-meshheading:2262494-... | lld:pubmed |
| pubmed-article:2262494 | pubmed:meshHeading | pubmed-meshheading:2262494-... | lld:pubmed |
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| pubmed-article:2262494 | pubmed:meshHeading | pubmed-meshheading:2262494-... | lld:pubmed |
| pubmed-article:2262494 | pubmed:articleTitle | The validity of canine platelet aggregometry in predicting vascular graft patency. | lld:pubmed |
| pubmed-article:2262494 | pubmed:affiliation | Department of Surgery, Loyola University Medical Center, Maywood, Illinois. | lld:pubmed |
| pubmed-article:2262494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2262494 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
