| pubmed-article:2260124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2260124 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:2260124 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:2260124 | lifeskim:mentions | umls-concept:C0056661 | lld:lifeskim |
| pubmed-article:2260124 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:2260124 | pubmed:dateCreated | 1991-1-29 | lld:pubmed |
| pubmed-article:2260124 | pubmed:abstractText | Microcystin-LR (MCLR) is a potent hepatotoxin that rapidly produces death in experimental animals. We have shown that cyclosporin A (CsA) can prevent the toxic and lethal effects of MCLR in mice. The LD50 of MCLR in mice is approximately 61 micrograms/kg, and 100 micrograms/kg produces death in 100% of treated mice. The minimum dose of CsA which prevented lethality in mice given 100 micrograms MCLR/kg i.p. was 10 mg/kg. This dose of CsA did not protect mice against higher doses of MCLR. Survival of all mice given 100 micrograms MCLR/kg was achieved if 10 mg CsA/kg was given 0.5-3 h prior to the MCLR but not if the CsA was co-administered or given after the MCLR. The results indicate that CsA effectively protects mice against a lethal dose of MCLR, but that the time of administration and the dose of CsA are critical determinants of the chemoprotective effects. | lld:pubmed |
| pubmed-article:2260124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2260124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2260124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2260124 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2260124 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:2260124 | pubmed:author | pubmed-author:StohsS JSJ | lld:pubmed |
| pubmed-article:2260124 | pubmed:author | pubmed-author:CaseyP JPJ | lld:pubmed |
| pubmed-article:2260124 | pubmed:author | pubmed-author:HermanskyS... | lld:pubmed |
| pubmed-article:2260124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2260124 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:2260124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2260124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2260124 | pubmed:pagination | 279-85 | lld:pubmed |
| pubmed-article:2260124 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:meshHeading | pubmed-meshheading:2260124-... | lld:pubmed |
| pubmed-article:2260124 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2260124 | pubmed:articleTitle | Cyclosporin A--a chemoprotectant against microcystin-LR toxicity. | lld:pubmed |
| pubmed-article:2260124 | pubmed:affiliation | Creighton University Health Sciences Center, Omaha, NE 68178. | lld:pubmed |
| pubmed-article:2260124 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2260124 | lld:pubmed |
