| pubmed-article:2258322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2258322 | lifeskim:mentions | umls-concept:C0003235 | lld:lifeskim |
| pubmed-article:2258322 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:2258322 | lifeskim:mentions | umls-concept:C0071804 | lld:lifeskim |
| pubmed-article:2258322 | lifeskim:mentions | umls-concept:C0643536 | lld:lifeskim |
| pubmed-article:2258322 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2258322 | pubmed:dateCreated | 1991-1-29 | lld:pubmed |
| pubmed-article:2258322 | pubmed:abstractText | Pradimicin FA-1 was produced via directed biosynthesis with substitution of D-serine for D-alanine in the 15-position of pradimicin A. This substitution was achieved by the addition of D-serine to the culture medium of Actinomadura hibisca P157-2. Likewise, pradimicin FA-2 was co-produced along with pradimicin FA-1 when the pradimicins A and C producing strain, A. hibisca A2493 was grown in D-serine-supplemented medium. The new pradimicin analogs share a common core structure of 5,6-dihydrobenzo[a]naphthacenequinone substituted by D-serine at C-15, but differ in the disaccharide moiety at C-5. Pradimicin FA-1 has an N-methylamino sugar and D-xylose. Pradimicin FA-2 is the des-N-methyl analog of pradimicin FA-1. The in vitro and in vivo antifungal activity of the analogs was comparable to that of pradimicin A. | lld:pubmed |
| pubmed-article:2258322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2258322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2258322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2258322 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2258322 | pubmed:issn | 0021-8820 | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:OkiTT | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:SawadaYY | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:YamamotoHH | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:MiyakiTT | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:NishioMM | lld:pubmed |
| pubmed-article:2258322 | pubmed:author | pubmed-author:HatoriMM | lld:pubmed |
| pubmed-article:2258322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2258322 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:2258322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2258322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2258322 | pubmed:pagination | 1223-9 | lld:pubmed |
| pubmed-article:2258322 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:meshHeading | pubmed-meshheading:2258322-... | lld:pubmed |
| pubmed-article:2258322 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2258322 | pubmed:articleTitle | New antifungal antibiotics pradimicins FA-1 and FA-2: D-serine analogs of pradimicins A and C. | lld:pubmed |
| pubmed-article:2258322 | pubmed:affiliation | Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan. | lld:pubmed |
| pubmed-article:2258322 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2258322 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2258322 | lld:pubmed |
