Comparison of the effects of intra-arterial and intravenous cisplatin on both limb tumor and lung metastases of transitional cell carcinoma RBT-1 in rats.

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Authors

Iwamoto Y, Sugioka Y

Affiliation

Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Abstract

The effects of intra-arterial (i.a.) and intravenous (i.v.) cisplatin on both limb tumor and lung metastases of transitional cell carcinoma RBT-1 in rats were compared. Tumor weights of limb tumors and the amount of lung nodules were evaluated on the eighth day after chemotherapy experiments. Both cisplatin 5 mg/kg i.a. and 5 mg/kg i.v. were administered to rats, but the intra-arterial method showed a significantly better effect on the limb tumor, whereas the intravenous method tended to be more effective on the lung metastases. Using the same dosage (5 mg/kg), the intra-arterial cisplatin group demonstrated a weaker level of nephrotoxicity and a smaller loss of body weight than seen in the intravenous cisplatin group. When a higher dose of cisplatin (6 mg/kg) was administered in the intra-arterial group, the antitumor effect on lung metastases and nephrotoxicity were similar to those of the group given cisplatin 5 mg/kg i.v. These data suggest that the dose of intra-arterial cisplatin can be slightly higher than that of intravenous cisplatin. Subsequently, a similar antitumor effect on lung metastases and a significantly better antitumor effect on primary tumor may be obtained at the equitoxic level.

PMID
2253498

Publication types

Comparative Study